Product Description

Aceclofenac 100 mg, Paracetamol 325 mg & Serratiopeptidase 15 mg Tablet IP is an oral fixed-dose combination for short-term management of pain and inflammation in adults. Aceclofenac (NSAID) provides anti-inflammatory and analgesic effects, paracetamol enhances pain relief and antipyresis, and serratiopeptidase (proteolytic enzyme) aids in reducing edema and promoting tissue repair.

Indicated for musculoskeletal disorders, dental/postoperative pain, and mild arthritis symptoms. Prescription-only; adjunct to rest/physiotherapy; efficacy in trials shows 50–70% pain reduction within 1–2 hours, but limited to 5–7 days to minimize risks.

Use 

• Relief of acute pain and inflammation in musculoskeletal conditions (e.g., low back pain, cervical spondylosis, sprains, strains, sports injuries)

• Management of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (short-term flare control)

• Adjunctive therapy for dental pain, postoperative pain/swelling, headaches, migraines, and dysmenorrhea (painful menstruation)

• Not indicated for chronic pain, fever alone, or non-inflammatory conditions; avoid in viral infections (e.g., dengue—paracetamol OK, but NSAID risks bleeding)

How it works

This triple combination targets pain, inflammation, and tissue healing through distinct mechanisms:

• Aceclofenac (100 mg): A phenylacetic acid NSAID that selectively inhibits cyclooxygenase (COX-2 > COX-1) enzymes, reducing prostaglandin synthesis. This decreases inflammation, pain, and fever at peripheral sites (e.g., joints/muscles). Onset: 30–60 minutes; duration 4–6 hours.

• Paracetamol (325 mg): Acts centrally in the brain (inhibits COX-3 variant) to elevate pain threshold and reduce fever via hypothalamic action; minimal anti-inflammatory effect. Complements aceclofenac for multimodal analgesia. Onset: 15–30 minutes; duration 4–6 hours.

• Serratiopeptidase (15 mg): A fibrinolytic proteolytic enzyme derived from silkworm bacteria that hydrolyzes proteins (e.g., fibrin, bradykinin) at inflammatory sites, promoting pus/debris breakdown, improving microcirculation, and reducing edema/swelling. Synergizes with NSAIDs for faster resolution.

Overall: Provides rapid symptomatic relief without opioids; not disease-modifying.

Benefits

• Multi-targeted relief: Combines analgesic (paracetamol), anti-inflammatory (aceclofenac), and enzymatic (serratiopeptidase) actions for 50–70% faster pain reduction vs. monotherapy (e.g., in post-op trials), effective for acute flares in arthritis/musculoskeletal issues.

• Enhanced recovery: Serratiopeptidase aids edema clearance (20–30% swelling reduction in studies), shortening downtime for injuries/surgeries.

• Fever and pain control: Paracetamol adds antipyretic effects for associated symptoms (e.g., headache/fever in dysmenorrhea), with lower GI risk than higher-dose NSAIDs alone.

• Convenience: Single tablet for short-term use (3–7 days) improves adherence; suitable for adults needing a non-narcotic option.

How to use

Swallow the sustained-release tablet orally with water, typically after meals; do not break, crush, or chew it. Follow the dosage prescribed by your healthcare provider. Take the medication at the same time each day to maintain consistent drug levels. If a dose is missed, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed one. Never take a double dose.

Side Effects

Common side effects (mild, GI-dominant; 5–15% incidence):

• Gastrointestinal: Nausea, vomiting, diarrhea, indigestion, heartburn, stomach pain, loss of appetite

• Central nervous system: Dizziness, drowsiness

Less common/rare but serious side effects (seek immediate medical attention):

• GI: Ulcers, bleeding, perforation (NSAID-related; symptoms: black stools, severe pain)

• Hepatic/Renal: Elevated liver enzymes (paracetamol/aceclofenac), kidney injury (reduced urine)

• Allergic: Rash, swelling, anaphylaxis; asthma exacerbation (NSAID sensitivity)

• Risks increase with duration/alcohol; use the lowest effective dose.

Safety Advice

Always consult a doctor before taking this medication, especially with pre-existing conditions. It is recommended to take it with food to prevent stomach upset. Avoid alcohol, which can increase the risk of liver damage. Do not combine with other painkillers containing acetaminophen without medical advice to prevent overdose. This medication is not advised for those with a history of stomach ulcers, severe liver or kidney disease, bleeding disorders, or pregnant or breastfeeding individuals without consulting a doctor. 

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

Is it safe to take this medication?

This medication is considered safe for most people, but some individuals may experience side effects such as nausea, vomiting, or stomach pain. If you have persistent issues, it is important to consult your doctor. 

Can I stop taking it once my pain is gone?

For short-term relief, you can stop taking this medicine once your pain is gone. However, if your doctor has advised you to continue, you should follow their instructions. 

Is it okay to take this medicine with alcohol?

No, you should avoid consuming alcohol when taking this medication. Alcohol can increase the risk of liver damage and excessive drowsiness. 

Can I take a higher dose than recommended?

No, you should not take a higher dose than your doctor has prescribed, as it could increase the risk of side effects. 

Can it damage my kidneys?

Prolonged use of this medication can potentially cause kidney damage, especially in those with pre-existing kidney conditions. Regular monitoring may be advised by your doctor during long-term treatment. 

Can I take this with other pain relievers?

You should not take this medication with other pain relievers containing aceclofenac or paracetamol without consulting your doctor, as this could lead to an overdose. 

Is it safe to take during pregnancy or while breastfeeding?

This medicine is not recommended for use during pregnancy, especially in the last trimester. If you are pregnant or breastfeeding, you should consult your doctor before taking it.