Product Description

Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm IP is a prescription topical medication used to treat acne vulgaris, including inflammatory and non-inflammatory lesions like pimples, blackheads, and whiteheads. It combines a retinoid (Adapalene) that promotes skin cell turnover with an antibiotic (Clindamycin) that targets acne-causing bacteria. This gel is effective for mild to moderate acne and helps reduce redness, swelling, and breakouts, but it should be used under medical supervision to minimise side effects like irritation.

Uses

1. Treatment of acne vulgaris, including:

• Inflammatory acne (e.g., papules and pustules).

• Non-inflammatory acne (e.g., comedones like blackheads and whiteheads).

2. It may also be used for acne associated with conditions like hormonal imbalances, but not for rosacea or fungal infections.

This gel is not suitable for severe cystic acne or non-bacterial skin conditions.

How it works

Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm IP combines two active ingredients for targeted acne therapy:

• Adapalene (0.1% w/w): A retinoid that normalises skin cell differentiation, unclogs pores, and reduces inflammation by binding to retinoic acid receptors, promoting faster turnover of skin cells and preventing new acne lesions.

• Clindamycin Phosphate (1% w/w): An antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, killing Propionibacterium acnes (now Cutibacterium acnes) and reducing bacterial overgrowth in pores.

Together, they address both the bacterial and comedonal aspects of acne, with effects visible in 2–4 weeks of consistent use.

Benefits

• Effective acne clearance: Reduces lesion count by 40–60% in clinical trials (e.g., from the Journal of the American Academy of Dermatology), improving skin texture and preventing scarring.

• Dual-action formula: Combines anti-inflammatory and antibacterial properties for faster results than single-agent therapies.

• Well-tolerated: Suitable for long-term use with proper application, helping maintain clear skin and boost confidence.

How to use

Wash your hands before and after applying Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel. Before using it, wash the affected area with water. Apply a small amount of Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel as a thin layer and gently rub on the clean and dry affected area of the skin at night before going to bed.

Side Effects

Common side effects (usually mild and transient):

• Skin reactions: Dryness, peeling, irritation, redness, or burning at the application site.

• Other: Itching, sun sensitivity, or temporary worsening of acne (initial purging).

Rare but serious side effects may include allergic reactions, severe irritation, or bacterial resistance. Discontinue use and consult a doctor if severe symptoms occur.

Safety Advice

• Alcohol Interaction: No significant interaction, but alcohol can exacerbate skin irritation; consult your doctor.

• Pregnancy and Breastfeeding: Classified as Pregnancy Category C (animal studies show risks, and human data are limited), so use only if the benefits outweigh risks. It may cause fetal harm; consult your doctor if pregnant or breastfeeding, as absorption is minimal but possible.

• Other Precautions: Use with caution in patients with eczema, rosacea, or sun-damaged skin, as it can worsen these conditions. Avoid prolonged use to prevent antibiotic resistance or skin atrophy. Not recommended for children under 12 or those with viral/fungal infections. Inform your doctor of all medications to avoid interactions (e.g., with other retinoids or antibiotics). Apply sunscreen daily, as it increases UV sensitivity. Regular skin checks are advised to monitor for irritation.

• Lifestyle Advice: Use gentle skincare products, avoid sun exposure, and follow up with your doctor for re-evaluation.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

Does Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm cause photosensitivity (increased sensitivity to sunlight)?

Yes, Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm may cause photosensitivity (increased skin sensitivity to sunlight) in the treated areas. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen and wear protective clothing while going out to prevent sunburn.

Is Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm safe for eczema patients?

No, Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm is not recommended for eczema (itchy, cracked, swollen, or rough skin) as it may increase the risk of severe irritation. Therefore, if you are suffering from eczema, inform your doctor before using Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm.

Does Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm cause skin irritation?

Yes, Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm may cause skin irritation or sensitivity as a side effect. However, if the irritation persists or worsens, stop using Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm and consult a doctor.

Can I use other acne products with Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm?

You are advised to use other acne products with Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel cautiously, as some products may increase side effects. It is recommended to use Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm at night and other products in the morning. However, please consult a doctor before using any other medicines or products with Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel.

Does Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel cause dryness of the skin?

Yes, Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel may cause dryness of the skin. You can use a moisturizer while using Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel to prevent dry skin. However, do not apply Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel and moisturiser at the same time, as it may reduce the effectiveness of Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm. Please consult a doctor before using other products with Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel.

Can I stop using Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel on my own?

No, you are not recommended to stop using Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel without consulting your doctor, as it may worsen the condition or cause recurring symptoms. Therefore, take Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel for as long as your doctor has prescribed it, and if you experience any difficulty while taking Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel, please consult your doctor.

What precautions do I need to follow while using Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel?

Do not use Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm for longer than the recommended duration. Avoid applying Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm on sunburned, windburned skin or on open wounds. Avoid using Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel 15gm in or around the eye area, lips, or inside of the nose. Rub it well and gently. Wash your hands after applying it.

For how long do I need to apply Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel?

You are advised to use Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel for as long as it is advised by your doctor, even if your symptoms begin to improve after a short time. If you stop using Adapalene 0.1%w/w and Clindamycin Phosphate 1%w/w Gel too early, your acne may worsen or recur.