Product Description

Alfuzosin 10 mg and Dutasteride 0.5 mg Tablets are a combination medication used to treat benign prostatic hyperplasia (BPH, enlarged prostate) in men. Alfuzosin, an alpha-1 adrenergic antagonist (alpha-blocker), relaxes smooth muscles in the prostate, bladder neck, and urethra, improving urine flow and reducing lower urinary tract symptoms (LUTS). 

Dutasteride, a 5-alpha-reductase inhibitor, blocks the conversion of testosterone to dihydrotestosterone (DHT), shrinking the prostate gland over time (by 20–30% in 6–12 months) and preventing further growth. Together, they provide rapid symptom relief and long-term disease modification, lowering risks of acute urinary retention (AUR) and need for surgery. It is for adult men only; not for women or children. Requires prescription; regular prostate checks advised.

Avoid it if you have severe hypotension, moderate-severe liver disease, or hypersensitivity. Baseline PSA and digital rectal exam (DRE) recommended.

Uses

Alfuzosin 10 mg and Dutasteride 0.5 mg Tablets are indicated for:

• Treatment of moderate-to-severe BPH symptoms (LUTS: difficulty urinating, weak stream, dribbling, incomplete emptying, hesitancy)

• Improvement of urinary flow rate and reduction of urgency/frequency/nocturia

• Reduction in prostate volume and prevention of BPH progression (e.g., AUR risk by 57%, surgery by 48% per trials)

• Adjunctive management in men with BPH and elevated PSA (but monitor for cancer)

Not for prostate cancer, urinary tract infection (treat separately), or acute AUR (use catheterization). Combine with lifestyle (e.g., limit fluids at night) for optimal results; assess with International Prostate Symptom Score (IPSS) every 3–6 months.

How it works

Alfuzosin 10 mg and Dutasteride 0.5 mg Tablets combine complementary mechanisms for BPH management:

• Alfuzosin (10 mg ER): Selectively antagonizes postsynaptic α1A-adrenoceptors (80% of prostate receptors), relaxing dynamic smooth muscle tone in the prostate, bladder neck, and urethra. This reduces urethral resistance, improving urine flow (peak effect in 1–2 weeks) without significantly affecting blood pressure (unlike non-selective alpha-blockers). The ER formulation provides steady release over 24 hours.

• Dutasteride (0.5 mg): Inhibits both type 1 and type 2 isoforms of 5α-reductase enzymes, reducing serum DHT levels by >90% (vs. 70% for finasteride). DHT drives prostate epithelial growth; inhibition shrinks the gland (static component reduction) and halts progression, with effects starting at 3 months and maximal at 6–12 months.

Synergistically, alfuzosin offers quick symptom relief, while dutasteride provides durable prostate reduction, improving quality of life and preventing complications.

Benefits

Alfuzosin 10 mg and Dutasteride 0.5 mg Tablets provide dual-action benefits for BPH: Alfuzosin delivers rapid relief (within days) from LUTS like weak stream, urgency, and nocturia (IPSS score improvement by 4–6 points), while dutasteride reduces prostate volume (by 25% average), lowering AUR/surgery risks and stabilizing PSA levels. The combination enhances efficacy over monotherapy (e.g., 70–80% symptom response vs. 50–60%), supports long-term management without frequent dosing, and improves sleep/sexual function in some men, though sexual side effects may occur.

How to use

Alfuzosin 10mg and Dutasteride 0.5mg tablets can be swallowed, crushed, chewed, or split. Maintaining a consistent daily intake helps sustain stable drug levels. Generally used long-term for the management of BPH.

Discontinuation: Do not stop taking the medication without consulting your doctor, as this may lead to a worsening of symptoms.

Side Effects

Most side effects are mild and from individual components, often improving over time. Common side effects (affecting 5–15% of patients) include:

• Dizziness or orthostatic hypotension (rise slowly, especially first dose)

• Headache or fatigue

• Nasal congestion or sinusitis

• Abnormal ejaculation (e.g., retrograde or reduced volume)

• Decreased libido or impotence (erectile dysfunction)

Less common but notable side effects:

• GI upset (nausea, diarrhea)

• Breast tenderness or enlargement (gynecomastia from dutasteride)

Safety Advice

• Alcohol: Limit, as it may enhance dizziness/hypotension from alfuzosin; avoid binge drinking.

• Pregnancy: Category X (contraindicated)—dutasteride is teratogenic (fetal genital abnormalities even via semen exposure). Women who are pregnant or may become pregnant must not handle crushed tablets or have unprotected sex with users (use condoms). Avoid blood donation for 6 months post-discontinuation.

• Breastfeeding: Not applicable (for men); if partner breastfeeding, semen exposure is negligible, but caution is advised.

• Driving/Operating Machinery: Alfuzosin may cause dizziness (especially initial doses or with alcohol); avoid until effects are known. Rise slowly from sitting/lying.

Storage Conditions

Store at a temperature below 30°C (86°F), in a cool, dry place away from direct sunlight, heat, and excessive moisture.

FAQs

What are Alfuzosin and Dutasteride used for?

The medication treats symptoms of benign prostatic hyperplasia (BPH), or an enlarged prostate, in men to improve urine flow and reduce prostate size.

How does it work?

Alfuzosin, an alpha-blocker, relaxes muscles in the prostate and bladder neck. Dutasteride, a 5-alpha-reductase inhibitor, shrinks the prostate by blocking DHT production.

Does it cure an enlarged prostate?

This medication does not cure BPH, but manages symptoms and can reduce prostate size for long-term control. Alfuzosin provides symptom relief quickly, while Dutasteride takes longer to shrink the prostate and improve symptoms.