Product Description

Amitriptyline Hydrochloride Tablets IP 10 mg belong to a class of medications called tricyclic antidepressants (TCAs), primarily used to treat major depressive disorder in adults. They are also indicated for neuropathic pain (nerve-related pain), prophylaxis of chronic tension-type headaches and migraine, and nocturnal enuresis (bedwetting) in children aged 6 years and older. Depression is a mood disorder characterized by persistent sadness, loss of interest, fatigue, and impaired daily functioning, often due to imbalances in brain neurotransmitters.

Amitriptyline works by inhibiting the reuptake of serotonin and norepinephrine (key neurotransmitters) in the brain, increasing their availability to improve mood regulation and reduce depressive symptoms. At lower doses, it also modulates pain pathways in the central nervous system, providing relief from neuropathic pain and headaches by blocking pain signal transmission.

Inform your doctor before use if you have allergies to TCAs, a recent heart attack, glaucoma, urinary retention, bipolar disorder, seizures, or thyroid issues. Contraindicated with MAO inhibitors (wait 14 days after stopping). Not recommended for children under 6 years or for depression/neuropathic pain in children (use only for enuresis). Avoid abrupt discontinuation to prevent withdrawal symptoms like nausea or irritability—taper gradually.

Uses

• Treatment of major depressive disorder (unipolar depression)

• Management of neuropathic pain (e.g., diabetic neuropathy, post-herpetic neuralgia)

• Prophylaxis of chronic tension-type headaches and migraine

• Treatment of nocturnal enuresis (bedwetting) in children aged 6 years and older

How it works

Amitriptyline Hydrochloride Tablets IP 10 mg contain amitriptyline, a tricyclic antidepressant that primarily inhibits the reuptake of serotonin and norepinephrine in the synaptic cleft, enhancing neurotransmission in mood-regulating brain pathways (e.g., limbic system). This helps alleviate depressive symptoms like low mood and anhedonia. For pain and headaches, it blocks sodium channels and modulates descending pain inhibitory pathways in the spinal cord and brain, reducing the perception and transmission of pain signals. At low doses (e.g., 10-25 mg), it has prominent analgesic effects with fewer anticholinergic side effects.

Benefits

• Effectively treats depression by balancing brain chemicals, improving mood, energy, and sleep patterns

• Provides significant relief from chronic neuropathic pain, reducing burning, tingling, or shooting sensations when other analgesics fail

• Prevents frequent tension headaches or migraines, decreasing their intensity and frequency for a better quality of life

• Helps control bedwetting in children by relaxing bladder muscles and deepening sleep without causing daytime drowsiness at low doses

• Cost-effective and versatile for multiple conditions; long-term use can reduce reliance on other medications like opioids for pain

How to use

• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.

• Take once daily at bedtime to minimize daytime sedation and leverage its sleep-promoting effects.

• For liquid formulations (if prescribed), shake well and use the provided measuring device (syringe or dropper) for accurate dosing.

• Dosage is individualized (e.g., 10-150 mg/day for adults); do not adjust without medical advice. Continue for at least 4-6 weeks to assess full benefits, and taper slowly when stopping.

Side Effects

Amitriptyline Hydrochloride Tablets 

• Drowsiness or sleepiness

• Dry mouth

• Constipation

• Headache

• Weight gain (due to increased appetite)

• Blurred vision

• Dizziness or orthostatic hypotension

• Irregular heartbeat (tachycardia)

• Nausea

• Urinary retention or slurred speech (less common at low doses)

• Nasal congestion

Safety Advice

• Avoid alcohol while taking Amitriptyline Hydrochloride Tablets IP 10 mg, as it can intensify sedation, dizziness, and respiratory depression.

• Use during pregnancy only if benefits outweigh risks (FDA pregnancy category D; potential fetal harm, including withdrawal symptoms in newborns). Not recommended during breastfeeding, as it passes into breast milk and may cause infant sedation or irritability.

• Safe for children ≥6 years only for enuresis (low dose, short-term); not for depression or pain in children due to suicide risk. Elderly patients may need lower doses due to increased sensitivity to anticholinergic effects.

• Monitor for worsening depression, suicidal thoughts (especially in young adults), or serotonin syndrome if combined with other serotonergic drugs. Avoid in patients with heart conduction issues or recent MAOI use.

• Do not drive or operate machinery until you know how it affects you, due to sedative and cognitive effects. Rise slowly from sitting/lying positions to prevent falls from hypotension.

Storage Conditions

• Store at temperatures below 30°C (86°F).

FAQs

What are the Amitriptyline Hydrochloride uses?

They are used to treat depression, neuropathic pain, chronic tension-type headaches, migraine prophylaxis in adults, and nocturnal enuresis (bedwetting) in children aged 6 years and older.

How does Amitriptyline Hydrochloride Tablets help treat depression?

It increases levels of serotonin and norepinephrine in the brain by blocking their reuptake, improving communication between nerve cells to regulate mood, reduce sadness, and enhance overall emotional balance.

How does Amitriptyline Hydrochloride Tablet help treat neuropathic pain?

It interrupts pain signal transmission in the brain and spinal cord by modulating neurotransmitters and sodium channels, providing relief from nerve-related pain like burning or tingling sensations.

Can I drive after taking Amitriptyline Hydrochloride 10mg Tablet?

Amitriptyline Hydrochloride Tablets IP 10mg Tablet causes sleepiness, drowsiness, and dizziness. Avoid driving or operating machinery if you are experiencing these symptoms.

Does Amitriptyline Hydrochloride use can cause weight gain?

Amitriptyline Hydrochloride Tablets can cause weight gain due to increased appetite. Follow a balanced diet and exercise regularly to maintain a healthy weight.

Can I stop taking Amitriptyline Hydrochloride Tablets if I feel well?

Do not discontinue Amitriptyline Hydrochloride Tablets without consulting your doctor, as it could lead to recurring symptoms. To treat your condition effectively, continue taking Amitriptyline Hydrochloride Tablets IP 10mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Amitriptyline Hydrochloride Tablets IP 10mg Tablet.

Do Amitriptyline Hydrochloride Tablets IP 10mg cause sexual disturbances?

Amitriptyline Hydrochloride Tablets IP 10mg Tablet may cause decreased sex drive, problems with erection, and orgasm. Consult your doctor if you have any concerns regarding this medication.

How to treat dry mouth?

Dry mouth could be a side effect of Amitriptyline Hydrochloride Tablets IP 10mg Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevent drying of the mouth.

Do Amitriptyline Hydrochloride Tablets IP 10mg cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing)?

Yes, orthostatic hypotension could be a side-effect of Amitriptyline Hydrochloride Tablets IP 10mg Tablet. Orthostatic hypotension is a sudden lowering of blood pressure leading to dizziness on standing. If this occurs, avoid standing or walking abruptly. Lie down and rise slowly only after feeling better. People taking Amitriptyline Hydrochloride Tablets IP 10mg Tablet are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.