Product Description

Cholecalciferol (Vitamin D3) 60,000 IU Solution 5 ml IP is a high-potency oral supplement containing 60,000 international units (IU) of cholecalciferol. The natural form of vitamin D is synthesized in the skin via sunlight exposure. It is prescribed to treat and prevent vitamin D deficiency, which can result from inadequate dietary intake, malabsorption, limited sun exposure, or increased needs (e.g., in obesity, renal disease). 

Vitamin D3 promotes intestinal calcium and phosphate absorption, essential for bone mineralization, muscle function, and overall health. This single-dose 5 ml solution is designed for rapid correction of deficiency in conditions like rickets, osteomalacia, osteoporosis, hypoparathyroidism, and latent tetany (hypocalcemic muscle spasms). It is not a daily multivitamin but a therapeutic agent for confirmed deficiency (serum 25-hydroxyvitamin D <20 ng/mL).

Uses

• Treatment and prevention of vitamin D deficiency states

• Management of rickets (in children) and osteomalacia (in adults)—bone softening due to impaired mineralization

• Adjunctive therapy for osteoporosis (to improve bone density and reduce fracture risk)

• Correction of hypocalcemia in hypoparathyroidism or latent tetany

• Support for chronic kidney disease-related mineral bone disorder (under medical supervision)

• Potential adjunctive role in immune modulation (e.g., reducing infection risk in deficient patients)

How it works

Cholecalciferol 60,000 IU Solution 5 ml IP replenishes vitamin D stores through the following metabolic pathway:

• Absorption: As a fat-soluble vitamin, it is absorbed in the small intestine (enhanced by dietary fats) and enters the bloodstream via chylomicrons.

• Activation: In the liver, it is hydroxylated to 25-hydroxyvitamin D (25-hydroxyvitamin D or calcifediol), the major circulating form used to assess vitamin D status. This is then converted in the kidneys (via 1-hydroxylase enzyme) to the active form, 1,25-dihydroxyvitamin D (1,25-dihydroxyvitamin D or calcitriol).

• Actions: Calcitriol binds to vitamin D receptors (VDR) in the intestines, promoting active transport of calcium and phosphate. It also regulates parathyroid hormone (PTH), supports bone remodeling (via osteoblasts/osteoclasts), and modulates immune cells (e.g., enhancing antimicrobial peptides). This restores calcium homeostasis, strengthens bones, and prevents deficiency-related complications.

Peak serum levels occur 12–24 hours post-dose; effects on calcium absorption begin within days, with full repletion in 4–8 weeks.

Benefits

• Rapidly corrects vitamin D deficiency, normalizing serum levels and alleviating symptoms like fatigue, muscle weakness, and bone pain.

• Enhances calcium/phosphate absorption, promoting bone mineralization and reducing risks of rickets, osteomalacia, and osteoporosis-related fractures.

• Supports skeletal health in osteoporosis by improving bone density (synergistic with calcium supplements).

• May bolster immune function in deficient individuals, potentially lowering respiratory infection risk (per observational studies).

• Aids in managing hypoparathyroidism by stabilizing calcium levels and preventing tetany.

• Convenient single-dose format for weekly therapy, improving adherence over daily low-dose options.
  

How to use

Take as directed: Use the solution exactly as prescribed by your doctor. The typical dose is one 5ml bottle per week, but this can vary depending on the severity of the deficiency. Take the medication at the same time and on the same day each week to maintain a consistent schedule. 5ml bottle containing a single dose/use (60,000 IU). Do not save any remaining solution for a later dose. You can take it directly from the bottle or mix it with food or a beverage.

Side Effects

Side effects are rare at therapeutic doses but primarily stem from vitamin D toxicity (hypervitaminosis D) due to overdose, leading to hypercalcemia (elevated blood calcium):

Common (mild, dose-related):

• Gastrointestinal: nausea, vomiting, constipation, loss of appetite, abdominal pain

• General: fatigue, weakness, headache

Serious (seek immediate medical attention—indicates toxicity):

• Renal: increased thirst, frequent urination, kidney stones, polyuria

• Neurological: dizziness, confusion, disorientation

• Cardiovascular: high blood pressure, irregular heartbeat (arrhythmias)

• Musculoskeletal: muscle weakness, bone pain

Toxicity threshold: Serum 25-OH D >150 ng/mL or calcium >10.5 mg/dL. Discontinue and hydrate if symptoms occur; chronic excess may cause nephrocalcinosis.

Safety Advice 

• Use only under medical supervision with baseline and follow-up tests (serum 25-OH D, calcium, renal function) to avoid toxicity.

• Contraindicated in: Hypercalcemia, hypervitaminosis D, malabsorption syndromes with hypercalcemia risk, or hypersensitivity.

• Caution in: Kidney/liver disease (impaired activation/clearance), sarcoidosis/granulomatous diseases (increased 1-hydroxylase activity), or hyperparathyroidism.

• Pregnancy/breastfeeding: Category C—use if benefits outweigh risks (e.g., for deficiency correction); monitor maternal/infant levels, as it passes into milk. Avoid high doses without advice.

• Interactions: May enhance effects of calcium supplements, thiazide diuretics (hypercalcemia risk), or steroids (reduced efficacy). Fat malabsorption drugs (e.g., orlistat) decrease absorption. Inform the doctor of all medications.

• Lifestyle: Combine with sun exposure (10–15 min/day) and a calcium-rich diet; limit alcohol, as it may impair absorption. Not a substitute for balanced nutrition.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

What is this solution used for?

This solution is used to treat and prevent vitamin D deficiency. It helps support bone health, reduces the risk of fractures, and aids calcium and phosphate absorption.

How does this solution work?

This solution contains Cholecalciferol (Vitamin D3), which helps the body absorb calcium and phosphates, both essential for maintaining strong bones and teeth.

Is this a prescription medication?

Yes, this is a high-potency vitamin D supplement and should be used under the supervision of a doctor.

Is this a cure for osteoporosis?

No, it is not a cure for osteoporosis, but it helps prevent and treat it by correcting vitamin D deficiency and aiding calcium absorption.

How should this solution be taken?

A doctor determines the dosage and frequency. The 5ml bottle is a single dose. It can be taken orally, with or without food, and is often recommended with a meal to improve absorption.

What if a dose is missed?

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, skip the missed one. Do not take a double dose. 

Can this be taken daily?

This is a high-potency dose and is typically prescribed weekly, not daily, to avoid toxicity.

How should this solution be stored?

Store it in a cool, dry place, away from direct sunlight, and out of the reach of children.

What are the common side effects?

Common side effects, primarily from an overdose, include constipation, nausea, vomiting, increased blood calcium levels, and increased urination.

Is it harmful if taken too much?

Yes, it can be harmful if taken in excess. An overdose can lead to high calcium levels, kidney stones, and other effects.

Can this solution cause high blood calcium (hypercalcemia)?

Yes, it can cause hypercalcemia, especially if the dosage is too high. This is why a doctor's supervision is necessary.

Is it safe during pregnancy or breastfeeding?

It is not recommended during pregnancy or breastfeeding unless specifically advised by a doctor. Higher doses require medical supervision during pregnancy.

Does it interact with alcohol?

Limit alcohol consumption, as it can affect calcium absorption.

Who should not take this solution?

Individuals with hypercalcemia (high blood calcium), hypervitaminosis D (excessive vitamin D), kidney stones, or severe kidney or liver disease should not take it.