{"product_id":"domperidone-tablets-10mg","title":"Domperidone Tablets IP 10 mg","description":"\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDomperidone Tablets IP 10 mg is an oral dopamine D2 receptor antagonist used as an antiemetic and prokinetic agent to treat nausea, vomiting, and gastrointestinal motility disorders. It primarily acts peripherally (limited blood-brain barrier penetration), blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) of the medulla and the upper GI tract.\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003eThis relieves nausea\/vomiting and enhances gastric emptying without significant central nervous system effects. Domperidone is indicated for short-term use in conditions like gastroparesis (delayed stomach emptying) and functional dyspepsia. It is not a cure but provides symptomatic relief; prolonged use is discouraged due to cardiac risks (e.g., QT prolongation).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eUses\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eRelief of acute nausea and vomiting from various causes (e.g., chemotherapy, radiotherapy, post-operative, or viral gastroenteritis)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eTreatment of gastroparesis (delayed gastric emptying) in adults and children \u0026gt;12 years\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eManagement of functional dyspepsia (indigestion with bloating, fullness, or epigastric pain)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAdjunctive therapy for reflux esophagitis or medication-induced nausea (e.g., from NSAIDs or levodopa)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eNot indicated for motion sickness (antihistamines preferred), chronic use, or in patients with mechanical GI obstruction\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow it works\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDomperidone acts as a selective peripheral dopamine D2 receptor antagonist:\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAntiemetic effect: Blocks D2 receptors in the CTZ (area postrema in the brain), preventing dopamine-mediated activation of the vomiting center. This inhibits emetic signals from the GI tract or vestibular system.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eProkinetic effect: Antagonizes inhibitory D2 receptors on cholinergic neurons in the upper GI tract, increasing acetylcholine release. This enhances gastric motility, accelerates emptying, and strengthens lower esophageal sphincter tone, reducing reflux and bloating.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eUnlike metoclopramide, it has minimal central penetration, reducing extrapyramidal side effects. Onset: 15–30 minutes orally; duration: 4–6 hours.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHyperprolactinemia (elevated prolactin) occurs as a side effect due to D2 blockade in the pituitary but is not part of the therapeutic mechanism.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eRapidly relieves nausea\/vomiting, improving comfort and reducing dehydration risk in acute settings.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eEnhances GI motility in gastroparesis\/dyspepsia, alleviating symptoms like bloating, early satiety, and postprandial discomfort.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eImproves quality of life in patients with delayed gastric emptying (e.g., diabetic gastroparesis) by promoting faster food transit and better nutrient absorption.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eShort-term use (≤7 days) minimizes risks while providing effective symptom control without sedation (unlike some antiemetics).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eUseful in specific populations (e.g., Parkinson's patients on levodopa) where nausea limits therapy adherence.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow to use\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDomperidone tablets should be swallowed whole with water, ideally 15 to 30 minutes before a meal, as this improves absorption. For adults and adolescents 12 years and older (weighing 35 kg or more): The usual dose is one 10 mg tablet, taken up to three times per day. To use Domperidone 10 mg tablets safely and effectively, follow your doctor's instructions carefully.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCommon side effects (usually mild and dose-related):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eGastrointestinal: Dry mouth, diarrhea, abdominal cramps\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eNeurological: Headache, dizziness, anxiety\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLess common but notable (due to hyperprolactinemia):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eIn women: Galactorrhea (milk discharge), menstrual irregularities, breast tenderness\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eIn men: Gynecomastia (breast enlargement), reduced libido\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSafety Advice\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eUse the lowest effective dose for the shortest duration (typically ≤7 days) to minimize QT prolongation and sudden cardiac death risk (black box warning in some regions).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eContraindicated in: Known QT prolongation, ventricular arrhythmias, severe cardiac disease (e.g., heart failure), GI hemorrhage\/perforation\/obstruction, prolactinoma, or hypersensitivity. Avoid in moderate-severe hepatic impairment (Child-Pugh B\/C).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eCaution in: Elderly (\u0026gt;60 years), renal impairment (reduce dose), hypokalemia\/magnesemia, or concurrent use with QT-prolonging drugs. Not recommended in pregnancy (Category B—use if benefits outweigh risks) or breastfeeding (passes into milk; avoid).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eInteractions: Potentiates QT risk with CYP3A4 inhibitors (e.g., ketoconazole, erythromycin—contraindicated), antifungals, antidepressants (e.g., SSRIs), or antiarrhythmics. Avoid with apomorphine or levodopa (enhanced effects). Inform the doctor of all medications.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eLifestyle: Avoid alcohol (may worsen dizziness); monitor for dehydration if vomiting persists. Not for self-medication—requires prescription due to cardiac concerns. Regular ECG monitoring in long-term\/at-risk patients.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eStorage Conditions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eStore at a temperature below 86°F (30 °C). Protect from light and moisture.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eFAQs\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eWhen should Domperidone be taken?\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFor most gastrointestinal conditions, it is best to take Domperidone 15–30 minutes before a meal to maximize its effect on digestion. It is typically taken up to three times a day, with doses spaced at least 8 hours apart.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eIs Domperidone safe for children?\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDomperidone tablets are generally not recommended for children under 12 years of age or weighing less than 35 kg. This is due to a lack of efficacy and safety data in this population. Specialist doctors might occasionally prescribe it for younger children off-label for specific conditions, but with careful monitoring.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eHow is Domperidone different from Metoclopramide?\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBoth are antiemetic (anti-nausea) and prokinetic drugs, but they work differently and have different side-effect profiles.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDomperidone has minimal penetration of the blood-brain barrier, resulting in a lower risk of central nervous system (CNS) side effects like drowsiness or involuntary muscle movements.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMetoclopramide crosses the blood-brain barrier more easily and is associated with a higher incidence of CNS side effects.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eCan Domperidone be used for acid reflux?\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYes, Domperidone can help relieve symptoms associated with acid reflux, such as heartburn, especially when related to delayed gastric emptying. In some cases, it is used in combination with antacids like proton pump inhibitors for more comprehensive relief.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eCan Domperidone be taken long-term?\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIt is recommended to use the lowest effective dose for the shortest possible duration, typically not exceeding seven days for nausea and vomiting. Long-term use or high doses of domperidone are associated with an increased risk of serious heart rhythm abnormalities.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eIs it safe to consume alcohol with Domperidone?\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNo, it is not recommended to drink alcohol while taking Domperidone. Alcohol can increase the risk of side effects such as dizziness and drowsiness and may also increase stomach acid production, counteracting the drug's effects.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eWhat are the storage conditions for Domperidone?\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDomperidone tablets should be stored in a tightly sealed container at room temperature. They should be kept away from excessive heat, moisture, and direct sunlight, and stored out of the reach of children.\u003c\/span\u003e\u003c\/p\u003e","brand":"Generic Remedy","offers":[{"title":"Domperidone Tablets IP 10 mg","offer_id":43299460939885,"sku":"GR073","price":9.38,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0619\/7349\/5917\/files\/Domperidone_tablets_10mg.png?v=1772187973","url":"https:\/\/www.genericremedy.com\/products\/domperidone-tablets-10mg","provider":"Generic Remedy","version":"1.0","type":"link"}