Product Description

Esomeprazole 40 mg (Enteric-Coated) & Domperidone 30 mg (Sustained Release) Capsules IP combine two gastrointestinal agents used to treat acid-related disorders.

Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production by irreversibly inhibiting the H+/K+ ATPase enzyme in gastric parietal cells. Domperidone is a dopamine D2 receptor antagonist that enhances gastrointestinal motility and accelerates gastric emptying, helping relieve nausea and vomiting.

This combination is effective in managing gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, peptic ulcers, and related symptoms caused by excess acid and delayed gastric emptying.

Uses

• Treatment and maintenance of gastroesophageal reflux disease (GERD)

• Management of Zollinger-Ellison syndrome and other hypersecretory conditions

• Healing and prevention of gastric and duodenal ulcers

• Relief of nausea, vomiting, bloating, and gastric fullness associated with delayed gastric emptying

• Treatment of erosive esophagitis and acid-related upper gastrointestinal symptoms

How it works

• Esomeprazole (40 mg, enteric-coated): Prevents acid secretion by irreversibly blocking the proton pump (H+/K+ ATPase) in stomach parietal cells. The enteric coating protects the drug from stomach acid, allowing absorption in the small intestine.

• Domperidone (30 mg, sustained release): Blocks dopamine receptors in the gastrointestinal tract and chemoreceptor trigger zone, enhancing gastric motility and accelerating gastric emptying, which reduces nausea and vomiting. The sustained-release formulation provides prolonged action.

Together, they reduce acid-related damage and improve gastric motility, alleviating symptoms such as heartburn, nausea, and bloating.

Benefits

• Potent and sustained reduction of gastric acid secretion

• Promotes healing of erosive esophagitis and peptic ulcers

• Improves symptoms of GERD, including heartburn and acid regurgitation

• Enhances gastric emptying, reducing nausea, vomiting, and bloating

• Improves overall gastrointestinal comfort and quality of life

How to use

• Take one capsule daily, preferably 1 hour before a meal (usually before breakfast) on an empty stomach for optimal absorption.

• Swallow the capsule whole with a glass of water; do not crush, chew, or open it.

• If prescribed with antibiotics (e.g., for H. pylori eradication), take as directed by your doctor.

• Consult your doctor before taking other medications to avoid interactions, especially antacids or other acid reducers.

• Do not exceed the prescribed duration; prolonged use requires medical supervision.

Side Effects

Common side effects (usually mild and transient):

• Dry mouth

• Stomach pain or discomfort

• Diarrhea or constipation

• Headache

• Flatulence (gas)

Rare but serious side effects (seek medical attention):

• Severe allergic reactions (rash, swelling, difficulty breathing)

• Irregular heartbeat or palpitations

• Signs of low magnesium (muscle cramps, tremors, dizziness) with prolonged use

• Persistent diarrhea or blood in the stools

Safety Advice

• Avoid alcohol consumption during treatment as it can increase stomach acid and worsen symptoms.

• Inform your doctor if you have liver disease, kidney problems, or electrolyte imbalances.

• Disclose all medications and supplements to avoid drug interactions (e.g., avoid nelfinavir, rilpivirine with esomeprazole).

• Report alarm symptoms such as unexplained weight loss, difficulty swallowing, or black stools immediately.

• Maintain hydration and a balanced diet to help manage side effects like diarrhea or dry mouth.

Storage Conditions

• Store capsules at a temperature below 30°C (86°F) in a cool, dry place.

FAQs

What is the use of Esomeprazole 40mg (Enteric-Coated) & Domperidone 30mg (Sustained Release)?

They are used to treat GERD, Zollinger-Ellison syndrome, stomach ulcers, and symptoms like nausea, vomiting, bloating, and heartburn.

How does Esomeprazole 40mg (Enteric-Coated) & Domperidone 30mg (Sustained Release) work?

Esomeprazole reduces stomach acid by blocking the proton pump, while domperidone improves stomach muscle contractions to reduce nausea and promote gastric emptying.

Does Esomeprazole 40mg (Enteric-Coated) & Domperidone 30mg (Sustained Release) cause diarrhoea?

Yes, diarrhea is a possible side effect. Drink plenty of fluids and eat non-spicy foods. Contact your doctor if diarrhea is severe or contains blood.

Can I lie down after having a meal?

Avoid lying down immediately after eating to prevent acid reflux. Elevate the head of your bed by 10–20 cm to keep the upper body elevated.

How to cope with dry mouth?

Limit caffeine, avoid smoking and alcohol-based mouthwashes, drink water regularly, and chew sugar-free gum or candy to stimulate saliva.

Is Esomeprazole 40mg (Enteric-Coated) & Domperidone 30mg (Sustained Release) used to treat nausea?

Esomeprazole 40mg (Enteric-Coated) & Domperidone 30mg (Sustained Release) contains domperidone, which helps in treating nausea and vomiting by increasing the movements and contractions of stomach muscles.

Is it safe to take Esomeprazole 40mg (Enteric-Coated) & Domperidone 30mg (Sustained Release) for longer durations?

Do not take Esomeprazole 40mg (Enteric-Coated) & Domperidone 30mg (Sustained Release) for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Esomeprazole 40mg (Enteric-Coated) & Domperidone 30mg (Sustained Release) for 14 days.