{"product_id":"glimepiride-2mg-metformin-1000mg","title":"Glimepiride 2mg \u0026 Metformin Sustained Release Tablet 1000mg IP","description":"\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMetformin Hydrochloride Sustained-release 1000mg \u0026amp; Glimepiride 2mg Tablets IP is a combination anti-diabetic medication for adults with type 2 diabetes mellitus. It combines a biguanide (Metformin) that improves insulin sensitivity and reduces glucose production, with a sulfonylurea (Glimepiride) that stimulates insulin release. This formulation is used when diet, exercise, and single-agent therapy are insufficient to control blood sugar, helping prevent complications like heart disease and neuropathy.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eUses\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eManagement of type 2 diabetes mellitus in adults, to lower blood glucose levels when lifestyle modifications and monotherapy with Metformin or Glimepiride are inadequate.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eAdjunctive therapy to improve glycemic control and reduce the risk of diabetes-related complications, such as cardiovascular events or kidney damage.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow it works\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMetformin Hydrochloride Sustained-release 1000mg \u0026amp; Glimepiride 2mg Tablets IP combines two mechanisms for comprehensive blood sugar control:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eMetformin Hydrochloride (1000 mg, sustained - release): Reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity. The sustained-release formulation ensures steady release, minimizing side effects like gastrointestinal upset.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eGlimepiride (2 mg): Stimulates pancreatic beta cells to release insulin by closing ATP-sensitive potassium channels, lowering blood glucose through increased insulin secretion.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTogether, they provide additive effects: Metformin addresses insulin resistance, while Glimepiride boosts insulin production, with an onset of 1–2 hours and sustained effects for 24 hours.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eEffective glycemic control: Lowers HbA1c by 1–2% in clinical trials, reducing fasting and post-meal glucose levels.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eComplementary action: Combines insulin sensitization with secretion enhancement, improving outcomes in patients not controlled on single therapy.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eConvenient dosing: Once-daily sustained-release tablet enhances adherence, with studies showing better long-term blood sugar management and reduced risk of hypoglycemia compared to immediate-release formulations.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow to use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTake Metformin Hydrochloride sustained-release 1000mg \u0026amp; Glimepiride 2mg Tablets IP exactly as prescribed, usually once daily with a meal to reduce stomach upset. Swallow the tablet whole with water; do not crush, break, or chew it, as this affects the sustained -release mechanism. Start with the lowest dose and adjust based on blood sugar monitoring. If you miss a dose, take it as soon as possible, but skip if it's near the next dose—do not double up. Always combine with a diabetic diet and exercise plan.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCommon side effects (often transient and manageable):\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eMetabolic: Hypoglycemia (low blood sugar), with symptoms like sweating, shakiness, or confusion.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eGastrointestinal: Nausea, vomiting, stomach pain, gas, bloating, or diarrhea.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eNeurological: Headache, dizziness.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eOther: Weight gain, metallic taste, rash, or vitamin B12 deficiency (with long-term use).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSeek medical help if side effects persist or include lactic acidosis (rare but serious with Metformin).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSafety Advice\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eAlcohol Interaction: Avoid alcohol, as it can increase the risk of lactic acidosis (with Metformin) and hypoglycemia (with Glimepiride).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003ePregnancy and Breastfeeding: Classified as Pregnancy Category C (animal studies show risks, and human data are limited), so use only if the benefits outweigh risks. Not recommended during pregnancy due to potential fetal harm; consult your doctor if breastfeeding, as both drugs may pass into breast milk.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eOther Precautions: Use with caution in patients with kidney or liver impairment, as dose adjustments are needed (e.g., avoid Metformin in severe renal disease). Monitor for hypoglycemia regularly, especially in the elderly. Inform your doctor of all medications to avoid interactions (e.g., with beta-blockers or sulfonamides). Not suitable for type 1 diabetes or diabetic ketoacidosis. Regular blood tests (e.g., for kidney function and vitamin B12 levels) are advised due to long-term risks.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eLifestyle Advice: Follow a low-sugar diet, exercise regularly, and monitor blood sugar. Do not drive if experiencing hypoglycemia symptoms.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eStorage Conditions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eStore at a temperature below 86°F (30 °C). Protect from light and moisture.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eFAQs\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eCan alcohol be consumed while taking this medication?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNo. Consuming alcohol can significantly increase the risk of both hypoglycemia and lactic acidosis and should be avoided.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat should be done if a dose is missed?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIf a dose is missed, take it as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed one. Do not take a double dose to make up for a missed one, as this can increase the risk of hypoglycemia.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWho should not take this medication?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDo not take this medication if you have type 1 diabetes, diabetic ketoacidosis, or severe kidney, liver, or heart problems. It is also not recommended for pregnant or breastfeeding women.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat should be done during surgery or imaging procedures?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eInform your doctor if any surgery involving general anesthesia or imaging procedures involving an iodinated contrast agent are scheduled. Your doctor may temporarily stop your treatment to avoid complications.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow long is this medication needed?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTreatment for type 2 diabetes is typically long-term. Do not stop taking this medication suddenly without consulting a doctor, as this can cause blood sugar levels to rise. Your doctor will determine the appropriate duration and dosage for treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Generic Remedy","offers":[{"title":"Glimepiride 2 mg Metformin Sustained Release Tablet 1000 mg IP","offer_id":42697731145837,"sku":"GR211","price":30.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0619\/7349\/5917\/files\/metformin_hydrochloride_sr_glimepiride_tablets_1000mg_2mg.png?v=1772521169","url":"https:\/\/www.genericremedy.com\/products\/glimepiride-2mg-metformin-1000mg","provider":"Generic Remedy","version":"1.0","type":"link"}