Product Description

Glucosamine 750 mg, Diacerein 50 mg & Methylsulfonylmethane 250 mg Tablets IP is a nutraceutical combination used as an adjunctive therapy for symptomatic relief in mild to moderate osteoarthritis (OA), particularly of the knee and hip. Osteoarthritis is a degenerative joint disease characterized by cartilage breakdown, leading to pain, stiffness, swelling, and reduced mobility. This formulation helps alleviate symptoms by supporting cartilage health, reducing inflammation, and improving joint lubrication, though it is not a disease-modifying agent, and evidence for long-term benefits is variable.

This tablet contains three active ingredients:

• Glucosamine (750 mg; a naturally occurring amino monosaccharide), which serves as a building block for glycosaminoglycans and proteoglycans, stimulates chondrocyte (cartilage cell) activity to promote cartilage repair and maintenance.

• Diacerein (50 mg; an anthraquinone derivative), which is metabolized to rhein, inhibits interleukin-1 (IL-1) and other pro-inflammatory cytokines to slow cartilage degradation and reduce joint inflammation.

• Methylsulfonylmethane (MSM) (250 mg; an organic sulfur donor), which provides sulfur for connective tissue synthesis and exhibits mild anti-inflammatory and analgesic effects by scavenging free radicals and modulating inflammatory pathways.

Together, they offer multi-faceted support: glucosamine and MSM aid structural integrity, while diacerein targets inflammation. Take as prescribed by your doctor, typically 1 tablet once or twice daily with food for 4-12 weeks (or longer for maintenance), to minimize gastrointestinal upset. Common side effects include nausea, diarrhea, indigestion, constipation, heartburn, and yellow urine discoloration (from diacerein), which are usually mild and transient. Serious risks (rare) include allergic reactions, elevated liver enzymes (from diacerein), or exacerbation of asthma/glucose intolerance (from glucosamine).

Inform your doctor before use if you have allergies to shellfish (glucosamine source), renal/hepatic impairment, diabetes (may affect blood sugar), or bleeding disorders. Not recommended for severe OA (use with analgesics/NSAIDs) or as monotherapy. Lifestyle measures (weight loss, exercise, physiotherapy) enhance efficacy. Regular monitoring (e.g., liver function) may be needed for long-term use.

Uses

• Symptomatic relief of pain, stiffness, and swelling in osteoarthritis (primarily knee and hip joints)

• Support for joint function and mobility in mild to moderate OA

• Adjunctive therapy to promote cartilage health and reduce inflammation in degenerative joint conditions

How it works

Glucosamine 750 mg, Diacerein 50 mg & Methylsulfonylmethane 250 mg Tablets IP combine a cartilage precursor, an anti-inflammatory agent, and a sulfur donor. Glucosamine is incorporated into cartilage matrix, stimulating proteoglycan synthesis and hyaluronic acid production to cushion joints and reduce friction. Diacerein inhibits IL-1 beta (a key mediator in OA pathogenesis), decreasing matrix metalloproteinase activity that breaks down cartilage and synovial inflammation, with effects building over 4-6 weeks. MSM donates sulfur for collagen and keratin formation while reducing oxidative stress and pro-inflammatory cytokines (e.g., TNF-alpha), providing analgesic benefits. Synergistically, they slow OA progression, alleviate symptoms, and improve joint lubrication without significant systemic effects.

Benefits

• Reduces osteoarthritis symptoms (pain, swelling, stiffness) in weight-bearing joints like knees and hips, enhancing daily activities and quality of life

• Supports cartilage repair and regeneration through glucosamine's role in glycosaminoglycan synthesis, potentially delaying joint degeneration when started early

• Provides anti-inflammatory action via diacerein and MSM, offering relief comparable to mild NSAIDs but with fewer GI risks for long-term use

• Improves joint mobility and flexibility, complementing non-drug therapies (e.g., exercise, weight management) for better outcomes

• Suitable as a nutraceutical adjunct for patients intolerant to analgesics, with a favorable safety profile for extended therapy (up to 6-12 months)

How to use

Swallow the tablet whole with a glass of water; do not chew, crush, or break it (to ensure proper absorption and avoid GI irritation).

• Take with or immediately after food (e.g., a meal) to reduce stomach upset from diacerein; typically 1 tablet once or twice daily as prescribed.

• Continue for the full recommended duration (e.g., 4-12 weeks initially); do not exceed the dose or stop abruptly without consulting your doctor to assess response.

• If you miss a dose, take it as soon as remembered unless near the next dose—do not double up. Combine with a balanced diet, low-impact exercise, and weight control for optimal results.

Side Effects

Glucosamine methylsulfonylmethane diacerein tablets side effects 

• Nausea or vomiting

• Diarrhea or constipation

• Indigestion or heartburn

• Abdominal pain or bloating

• Urine discoloration (yellowish; harmless, from diacerein)

• Headache or dizziness

• Skin rash or itching (allergic reaction)

• Fatigue or mild joint pain (initial flare)

• Rare but serious: Elevated liver enzymes, severe GI upset (e.g., colitis), hyperglycemia (in diabetics), or hypersensitivity reactions

Safety Advice

• Limit alcohol while taking Glucosamine 750 mg, Diacerein 50 mg & Methylsulfonylmethane 250 mg Tablets IP, as it may increase liver strain (from diacerein) or GI irritation—consult your doctor for personalized advice.

• Use during pregnancy only if benefits outweigh risks (limited data; category C—glucosamine is naturally occurring, but diacerein may affect fetal development; avoid unless prescribed). Not recommended during breastfeeding, as components may pass into milk (monitor infant for diarrhea or rash).

• Caution in renal impairment (reduce dose for diacerein; CrCl <30 mL/min—avoid), hepatic disease (monitor LFTs), diabetes (glucosamine may raise blood sugar), or shellfish allergy (use vegan glucosamine alternative). Elderly patients may need lower doses due to slower metabolism.

• Inform your doctor of all medications to avoid interactions (e.g., warfarin—glucosamine may enhance anticoagulation; avoid with strong laxatives due to diacerein). Not for children under 18 years without advice. Discontinue if severe side effects occur and seek medical help.

• Hydrate well to minimize urine changes; report persistent GI symptoms or yellowing of skin/eyes (jaundice).

Storage Conditions

• Store at temperatures below 30°C (86°F).

FAQs

What are these tablets used for?

These tablets are primarily used to treat and manage the symptoms of osteoarthritis, including joint pain, stiffness, swelling, and reduced mobility. 

How long does it take to feel relief?

You may not feel immediate relief. It can take several weeks or even months of consistent use to notice a significant improvement in pain and joint function. 

Is this a steroid?

No, this medication is not a steroid. 

How should I take these tablets?

You should take these tablets exactly as your doctor advises, typically once or twice a day. Taking the tablets with food can help prevent an upset stomach. 

What if I miss a dose?

If you miss a dose, take it as soon as you remember. If it's nearly time for your next dose, skip the missed dose and proceed with your regular dosing schedule. Do not take a double dose. 

What if side effects persist?

If side effects are persistent or severe, you should contact your doctor immediately. 

What are the contraindications for this medication?

• Known hypersensitivity or allergies to any of the ingredients (including shellfish allergy due to glucosamine)

• Severe liver or kidney disease

• Bleeding disorders or those on blood-thinning medication 

Should I be careful if I have diabetes?

Yes, use caution if you have diabetes. Glucosamine can potentially affect insulin sensitivity and blood sugar levels, so regular monitoring is advised. 

Can pregnant or breastfeeding women take this?

No, pregnant or breastfeeding women should consult their doctor before using this medication, as its safety in these situations is not well-established. 

Can I take these tablets with other painkillers?

Consult your doctor before combining this medication with other painkillers to avoid potential drug interactions. 

Is it safe for long-term use?

When taken as prescribed by a doctor, it can be safe for long-term management of joint health. 

Can these tablets help with sports injuries?

While primarily for osteoarthritis, this combination may also help with cartilage repair from sports injuries. However, you should always consult a doctor for the appropriate treatment. 

What are the storage conditions for Glucosamine methylsulfonylmethane and diacerein tablets?

Store this medicine in its original, tightly closed container or pack, following the storage instructions provided on the label or packaging. Dispose of the unused medicine. Ensure that pets, children, and others do not consume it.

Can the use of Glucosamine methylsulfonylmethane diacerein tablets cause indigestion?

Yes, the tablet may cause indigestion. Take it with or after food to avoid indigestion. Talk to your doctor if indigestion persists.