Product Description

Leflunomide Tablets IP 20mg is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis in adults. Rheumatoid arthritis is an autoimmune disease where the immune system attacks joint tissues, causing pain and damage.

Psoriatic arthritis is an inflammatory arthritis associated with psoriasis (red, scaly skin patches). Leflunomide contains leflunomide, an immunomodulatory agent that inhibits pyrimidine synthesis, essential for rapidly dividing immune cells, thereby suppressing overactive immunity and reducing pain, inflammation, and swelling. It requires regular monitoring due to potential side effects.

Uses

• Treatment of active rheumatoid arthritis and psoriatic arthritis in adults to reduce symptoms and slow disease progression.

• It is not a cure and is used as part of a comprehensive treatment plan, not for acute flares alone.

How it works

Leflunomide Tablets IP 20mg contains leflunomide, which inhibits dihydroorotate dehydrogenase, an enzyme involved in pyrimidine synthesis. This reduces the proliferation of immune cells, suppressing the overactive immune response that causes inflammation and joint damage in rheumatoid and psoriatic arthritis.

Benefits

Leflunomide is a disease-modifying antirheumatic drug (DMARD) that helps reduce inflammation, redness, swelling, and pain in affected joints. It slows disease progression, improves joint function, and enhances quality of life for patients with rheumatoid or psoriatic arthritis, but it does not cure the conditions and requires long-term use under medical supervision.

How to use

Take Leflunomide Tablets IP 20mg with or without food, as advised by your doctor. Swallow the tablet whole with water; do not crush or chew it. Follow the prescribed dose and duration; regular monitoring is required.

Side Effects

Common side effects include:

• Diarrhea, nausea, or stomach pain.

• Indigestion or rash.

• Hair loss.

These are usually mild; consult your doctor if severe or persistent. Serious side effects may include liver damage, severe infections, high blood pressure, or peripheral neuropathy. Seek immediate medical attention for signs like jaundice, unexplained bleeding, or severe rash.

Safety Advice

• Alcohol: Avoid alcohol, as it may increase liver damage risk; consult your doctor.

• Pregnancy and Breastfeeding: Not recommended during pregnancy due to risk of birth defects; use effective contraception during treatment and for at least 2 years after stopping. It may pass into breast milk, so consult your doctor before breastfeeding.

• Liver Impairment: Use with caution or avoid if you have liver disease; regular liver function tests are advised.

• Other Precautions: Inform your doctor of any infections, kidney issues, or blood disorders, as leflunomide can suppress the immune system. Avoid live vaccines. May interact with other DMARDs (e.g., methotrexate) or drugs affecting the liver. Monitor blood pressure and report any new symptoms promptly.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

How does Leflunomide Tablets IP 20mg work?

Leflunomide Tablets IP 20mg is a disease-modifying antirheumatic drug (DMARD) that stops the DNA (genetic material) of the provoked immune system cells required for their survival. Thus, it aids in reducing inflammation, redness, and swelling in the affected area (particularly joints).

Do Leflunomide Tablets IP 20mg cause diarrhoea?

Leflunomide Tablets IP 20mg may cause diarrhoea. Stay well-hydrated and consume bland, non-spicy foods if you have diarrhea. If you notice blood in your stools (tarry stools) or experience severe diarrhea, contact your doctor. Avoid using anti-diarrheal medication without consulting your doctor.

How long does Leflunomide Tablets IP 20mg take to work?

It may take 4 to 6 weeks to start noticing any benefits.. In some cases, it might also take 6 months for you to feel the full effect of Leflunomide Tablets IP 20mg. Take Leflunomide Tablets IP 20mg for as long as your doctor has prescribed to treat your condition effectively.

In which conditions should I avoid taking Leflunomide Tablets IP 20mg?

Notify your doctor if you have liver disease, kidney disease, a weakened immune system, or serious infections such as pneumonia or tuberculosis (TB).