{"product_id":"metformin-pr-500mg-sitagliptin-50mg","title":"Sitagliptin 50mg + Metformin 500mg tablets","description":"\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMetformin 500mg \u0026amp; Sitagliptin 50mg Tablet is a fixed-dose oral combination antidiabetic agent for adults with type 2 diabetes mellitus (T2DM). Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, enhances incretin activity, thereby promoting glucose-dependent insulin secretion. Metformin, a biguanide, suppresses hepatic glucose production and improves insulin sensitivity\u003c\/span\u003e\u003cspan\u003e. Their synergistic mechanisms provide superior glycemic control (fasting\/postprandial) compared to monotherapy. Prescription-only; adjunct to diet\/exercise; lowers HbA1c by 1–1.5% in clinical trials (e.g., TECOS study extensions).\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eUses\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eManagement of T2DM in adults when diet, exercise, and monotherapy (e.g., metformin alone) fail to achieve targets (HbA1c \u0026lt;7%)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eImprovement of glycemic parameters (fasting plasma glucose, postprandial glucose) to prevent complications (e.g., neuropathy, cardiovascular events)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eAdjunctive therapy in overweight T2DM patients (metformin supports ~1–2 kg weight loss)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eNot indicated for type 1 diabetes, diabetic ketoacidosis (DKA), gestational diabetes, or severe renal impairment (eGFR \u0026lt;30 mL\/min)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow it works\u003c\/strong\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThis combination leverages complementary pathways for effective, glucose-dependent control:\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eSitagliptin (50 mg): Inhibits DPP-4 enzyme, increasing active incretin hormones (GLP-1, GIP) post-meal. This stimulates insulin release from pancreatic beta-cells only when glucose is elevated and suppresses glucagon from alpha-cells, reducing hepatic glucose output. No effect on insulin when normoglycemic—lowers hypo risk. Onset: 1–3 hours; duration 24 hours.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eMetformin (500 mg): Activates AMPK to inhibit gluconeogenesis in the liver (~25–30% fasting glucose reduction), enhances peripheral insulin sensitivity (muscle glucose uptake), and slows intestinal carbohydrate absorption. \u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSynergy: Sitagliptin amplifies metformin's effects on postprandial glucose; overall, no weight gain or significant hypo. Steady-state: 2–3 days.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eEnhanced glycemic control: Reduces HbA1c by 0.7–1.5% (superior to components alone in T2DM trials, e.g., 12-week studies showing 1.0% drop vs. 0.6% for metformin monotherapy), stabilizing both fasting and postprandial levels.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eLow hypoglycemia risk: Sitagliptin's glucose-dependent action avoids excessive insulin secretion (hypo incidence \u0026lt;1% vs. 10–20% with sulfonylureas), safer for the elderly or those with variable eating.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eCardiovascular neutrality: No increased heart risk (per TECOS trial); metformin may offer protective effects (e.g., 10–15% CV event reduction in meta-analyses).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow to use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSwallow the sustained-release tablet orally with water, typically after meals; do not break, crush, or chew it. Follow the dosage prescribed by your healthcare provider. Take the medication at the same time each day to maintain consistent drug levels. If a dose is missed, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed one. Never take a double dose.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCommon side effects (mild, transient; 5–10% incidence):\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eGastrointestinal (metformin-dominant): Nausea, vomiting, diarrhea, gas, bloating, stomach pain, indigestion\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eGeneral: Headache, metallic taste (metformin), upper respiratory symptoms (runny\/stuffy nose, sore throat—sitagliptin)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLess common\/rare but serious side effects (seek immediate medical attention):\u003c\/span\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eMetabolic: Lactic acidosis (rare \u0026lt;1\/100,000; symptoms: fatigue, hyperventilation—metformin risk)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eHypoglycemia: If combined with insulin\/sulfonylureas (dizziness, sweating)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eOther: Vitamin B12 deficiency (long-term: anemia, neuropathy—monitor); allergic rash, pancreatitis (sitagliptin rare \u0026lt;0.1%)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e \u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSafety Advice\u003c\/strong\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDo not stop taking this medication abruptly, even if your blood sugar levels are controlled. Suddenly discontinuing it can cause your blood sugar to spike to dangerously high levels. It must be swallowed whole. Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed and increase side effects.\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eWhile this medication has a low risk of causing hypoglycemia, it can happen, especially if you are taking other antidiabetic drugs. Be aware of symptoms like dizziness, shakiness, sweating, and confusion. Limit or avoid alcohol, as excessive consumption can increase the risk of lactic acidosis and low blood sugar.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eStorage Conditions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eStore at a temperature below 86°F (30 °C). Protect from light and moisture.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eFAQs\u003c\/strong\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eDoes this medication cure type 2 diabetes?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNo, it helps manage and control blood sugar levels, but does not cure diabetes.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eIs this medication suitable for type 1 diabetes?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNo, this medication is only for the treatment of type 2 diabetes.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow should this medication be taken?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTake one tablet daily with a meal, preferably in the evening, to minimize gastrointestinal side effects. Tablets should be swallowed whole and not crushed, chewed, or broken.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eCan this medication be stopped once blood sugar is under control?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNo, do not stop taking this medication without consulting a doctor. Stopping abruptly can cause blood sugar levels to increase.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eCan alcohol be consumed with this medication?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAvoid excessive alcohol consumption, as it can increase the risk of lactic acidosis, a serious condition.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eCan one drive while taking this medication?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eExercise caution when driving or operating machinery, as the medication can cause dizziness or low blood sugar, which may affect concentration.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eDoes it cause low blood sugar (hypoglycemia)?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThis combination has a low risk of causing hypoglycemia, but the risk increases if taken with other diabetes medications like insulin.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eIs it safe for pregnant or breastfeeding women?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThis medication is generally not recommended during pregnancy or breastfeeding. Discuss the risks and benefits with a doctor if pregnant, planning to become pregnant, or breastfeeding\u003c\/span\u003e\u003cspan\u003e.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWho should not take this medication?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThis medication should not be taken if there is a history of allergies to its components, severe kidney or liver disease, heart problems like congestive heart failure, or diabetic ketoacidosis.\u003c\/span\u003e\u003c\/p\u003e","brand":"Generic Remedy","offers":[{"title":"Default Title","offer_id":67816055930989,"sku":"GR611","price":60.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0619\/7349\/5917\/files\/WhatsAppImage2026-10-21at5.03.09PM.jpg?v=1792582789","url":"https:\/\/www.genericremedy.com\/products\/metformin-pr-500mg-sitagliptin-50mg","provider":"Generic Remedy","version":"1.0","type":"link"}