Product Description

Pantoprazole 40 mg & Domperidone 30 mg Prolonged Release Capsules IP are a fixed-dose combination of a proton pump inhibitor (PPI) and a prokinetic agent, primarily used to treat gastroesophageal reflux disease (GERD), acid reflux, heartburn, inflammation of the esophagus (esophagitis), and peptic ulcers (gastric or duodenal). These conditions arise from excessive stomach acid production or a weakened lower esophageal sphincter, leading to acid backflow, irritation, pain, and potential tissue damage in the esophagus, stomach, or duodenum. The prolonged-release (PR) formulation of domperidone ensures sustained action over 12-24 hours.

This capsule contains two active ingredients:

• Pantoprazole (a PPI), which irreversibly blocks the H+/K+ ATPase enzyme (proton pump) in gastric parietal cells, suppressing acid secretion by up to 99% to promote healing and relieve symptoms.

• Domperidone (a peripheral dopamine D2 receptor antagonist), which enhances gastrointestinal motility, accelerates gastric emptying, strengthens the esophageal sphincter, and blocks the chemoreceptor trigger zone (CTZ) in the brain to prevent nausea and vomiting without significant central nervous system penetration.

Together, they provide dual benefits: acid suppression for mucosal protection and motility enhancement for faster symptom relief. Take as prescribed by your doctor, typically once daily before a meal for 4-8 weeks (or longer for maintenance). Common side effects include headache, diarrhea, nausea, abdominal pain, flatulence, dizziness, and joint pain (arthralgia), which are usually mild and transient. Serious risks with long-term use include nutrient deficiencies (e.g., vitamin B12, magnesium), bone fractures, or cardiac effects (e.g., QT prolongation from domperidone).

Uses

• Treatment of gastroesophageal reflux disease (GERD) and related heartburn/acid reflux

• Management of erosive esophagitis (inflammation of the food pipe)

• Healing and prevention of peptic ulcers (gastric/duodenal), including those induced by NSAIDs

• Relief of dyspepsia (indigestion) with associated nausea or bloating

How it works

Pantoprazole 40 mg & Domperidone 30 mg Prolonged Release Capsules IP combine a PPI (pantoprazole) and a prokinetic (domperidone). Pantoprazole inhibits the final step of acid production by binding to the proton pump (H+/K+ ATPase) on the secretory surface of gastric parietal cells, reducing both basal and stimulated acid output to allow healing of acid-damaged tissues in the esophagus, stomach, and duodenum. Domperidone antagonizes dopamine receptors in the GI tract, increasing peristalsis and gastric emptying to reduce reflux and bloating, while peripherally blocking the CTZ to suppress nausea and vomiting signals without crossing the blood-brain barrier. The prolonged-release mechanism provides steady domperidone delivery for extended symptom control.

Benefits

• Reduces excessive stomach acid to heal ulcers, esophagitis, and prevent complications like Barrett's esophagus or strictures

• Improves GI motility to alleviate bloating, fullness, regurgitation, and indigestion faster than acid suppression alone

• Effectively controls nausea and vomiting associated with GERD or hyperacidity, enhancing daily comfort and appetite

• Prolonged-release formulation allows once-daily dosing for better adherence and sustained 24-hour protection

• Suitable for short- or long-term use in acid-related disorders, reducing the need for multiple medications

How to use

• Swallow the capsule whole with a glass of water; do not crush, break, chew, or open it (to maintain the prolonged-release properties).

• Take once daily, preferably 30-60 minutes before the first meal of the day, for optimal acid suppression and motility effects.

• Continue for the full prescribed course (e.g., 4-8 weeks for initial treatment); do not stop early to avoid acid rebound.

• If a dose is missed, take it as soon as possible unless it's near the next dose—do not double up.

Side Effects

Pantoprazole and Domperidone tablet side effects

• Headache

• Diarrhea or constipation

• Nausea or vomiting

• Abdominal pain

• Flatulence (gas)

• Dizziness

• Dry mouth

• Joint pain (arthralgia)

• Rash or itching

• Rare but serious: Low magnesium/vitamin B12 (leading to fatigue, anemia), bone fractures, QT prolongation (irregular heartbeat), or hypersensitivity reactions

Safety Advice

• Avoid alcohol while taking Pantoprazole 40 mg & Domperidone 30 mg Prolonged Release Capsules IP, as it can increase stomach acid, worsen dehydration, and heighten side effects like dizziness or liver strain.

• Use during pregnancy only if benefits outweigh risks (FDA category B for pantoprazole, C for domperidone; limited human data—consult your doctor). Not recommended during breastfeeding, as both may pass into breast milk and cause infant effects like sedation or cardiac issues.

• Caution in patients with liver impairment (pantoprazole/domperidone metabolism reduced; monitor closely) or heart conditions (domperidone may prolong QT—avoid with antiarrhythmics or other QT-prolonging drugs). Dose adjustment needed for severe kidney disease.

• Long-term use (>1 year) requires monitoring for nutrient deficiencies (e.g., B12, magnesium, calcium) and bone density; supplements may be advised. Inform your doctor of all medications to avoid interactions (e.g., with clopidogrel, warfarin, or antifungals).

• Do not self-medicate for heartburn >14 days; seek medical evaluation for persistent symptoms.

Storage Conditions

• Store at temperatures below 30°C (86°F).

FAQs

What are the Pantoprazole and Domperidone tablet uses for?

They are used to treat GERD, heartburn due to hyperacidity, esophagitis (food pipe inflammation), and peptic ulcers by reducing acid and improving digestion.

How do Pantoprazole and Domperidone tablets work?

Pantoprazole blocks the proton pump to reduce stomach acid production, while domperidone speeds up food movement through the stomach, reduces bloating, and blocks nausea signals in the brain.

How long can I take Pantoprazole and Domperidone?

Take for as long as prescribed by your doctor (typically 4-8 weeks for initial treatment, or longer for maintenance). Do not exceed without review to avoid long-term risks like nutrient deficiencies.

Can Pantoprazole & Domperidone cause brittle bones?

Yes, taking Pantoprazole and Domperidone for a very long time can cause calcium depletion in the body, leading to weakening of bones. Hence, a calcium and vitamin D supplement is recommended along with the Capsule to replenish calcium depletion in the body.

Do Pantoprazole and Domperidone tablets interfere with or affect laboratory test reports?

Yes. Pantoprazole & Domperidone Capsule can alter certain medical tests, such as those for neuroendocrine tumours (secretin stimulation test) and urine screening tests for tetrahydrocannabinol (THC). So, before undergoing such diagnostic tests, contact your doctor.

How can I manage my long-term Pantoprazole and Domperidone tablet side effects?

Prolonged intake of  Pantoprazole and Domperidone  Capsule may weaken your bones and lower your haemoglobin level. Your doctor may prescribe you Vitamin B12 to enhance haemoglobin and calcium/vitamin D/magnesium supplements for bone health.

Can I take Pantoprazole and Domperidone together?

A combination of pantoprazole and domperidone is effective and safe.

Can I take Pantoprazole 40mg & Domperidone 30mg Capsule on my own for acidity?

No, Pantoprazole and Domperidone capsule is a prescribed drug with minimal side effects. Only take it if your doctor has recommended it to you for acidity.