Product Description

Rabeprazole 20 mg (Enteric Coated) & Domperidone 30 mg (Sustained Release) Capsules IP belong to a class of medications combining a proton pump inhibitor (PPI) and a prokinetic agent, primarily used to treat gastroesophageal reflux disease (GERD), acid reflux, heartburn, peptic ulcers (gastric or duodenal), and dyspepsia (indigestion). They are also indicated for Zollinger-Ellison syndrome (ZES), a rare condition involving excessive acid production due to gastrin-secreting tumors. GERD occurs when the lower esophageal sphincter weakens, allowing stomach acid to reflux into the esophagus, causing irritation, burning sensation (heartburn), and potential damage to the esophagus, stomach, or duodenum.

This capsule contains two active ingredients:

• Rabeprazole (a PPI), which irreversibly inhibits the H+/K+ ATPase enzyme (proton pump) in parietal cells of the stomach lining, reduces gastric acid secretion by up to 99% and promotes healing of acid-related damage. The enteric coating protects it from stomach acid for targeted release in the intestine.

• Domperidone (a dopamine D2 receptor antagonist and prokinetic), which enhances gastric motility and emptying, strengthens the lower esophageal sphincter, and blocks the chemoreceptor trigger zone (CTZ) in the brain to prevent nausea and vomiting. The sustained-release (SR) formulation provides prolonged action (up to 12-24 hours).

Together, they provide symptomatic relief and healing by controlling acid production and improving gastrointestinal transit. Take as prescribed by your doctor, typically once daily before breakfast for 4-8 weeks (or longer for maintenance in GERD/ZES). Common side effects include headache, diarrhea, nausea, abdominal pain, flatulence, dizziness, and dry mouth, which usually resolve spontaneously. Serious risks include long-term PPI use leading to vitamin B12 deficiency, hypomagnesemia, bone fractures (osteoporosis), or increased infection risk (e.g., C. difficile); domperidone may cause QT prolongation (heart rhythm issues) in susceptible patients.

Uses

• Treatment of gastroesophageal reflux disease (GERD) and acid reflux symptoms (e.g., heartburn, regurgitation)

• Management of peptic ulcers (gastric/duodenal) and prevention of ulcer recurrence (e.g., with NSAIDs)

• Relief of dyspepsia (indigestion) and associated nausea/vomiting

• Treatment of Zollinger-Ellison syndrome (hypersecretory conditions)

How it works

Rabeprazole 20 mg (Enteric Coated) & Domperidone 30 mg (Sustained Release) Capsules IP combine a PPI (rabeprazole) and a prokinetic (domperidone). Rabeprazole suppresses basal and stimulated gastric acid secretion by binding to and inhibiting the proton pump (H+/K+ ATPase) on the luminal surface of gastric parietal cells, reducing acid-mediated damage to the esophagus, stomach, and duodenum. The enteric coating ensures it reaches the small intestine intact for optimal activation. Domperidone peripherally antagonizes dopamine receptors, increasing peristalsis in the upper GI tract, accelerating gastric emptying, and inhibiting the CTZ to control nausea without crossing the blood-brain barrier significantly. The SR form provides steady release for sustained motility enhancement. This dual action heals erosions, relieves symptoms, and prevents complications like Barrett's esophagus.

Benefits

• Effectively reduces stomach acid production, heals acid-related damage, and prevents ulcer formation or recurrence

• Improves esophageal clearance and motility, alleviating GERD symptoms like heartburn, regurgitation, and bloating faster than PPI monotherapy

• Controls nausea and vomiting associated with dyspepsia or GERD, enhancing overall GI comfort

• Suitable for short- or long-term use in hypersecretory conditions like ZES, reducing the need for surgery

• Enteric and SR formulations minimize GI irritation and provide 24-hour coverage with once-daily dosing

How to use

• Swallow the capsule whole with a glass of water; do not crush, chew, break, or open it (to preserve the enteric/SR properties).

• Take once daily, preferably 30-60 minutes before the first meal of the day, for optimal acid suppression and motility effects.

• Continue for the full prescribed duration (e.g., 4-8 weeks for initial GERD/ulcer treatment); do not stop early to avoid symptom rebound.

• If you miss a dose, take it as soon as you remember, unless close to the next dose—do not double up.

Side Effects

Rabeprazole sodium and domperidone capsule side effects

• Headache

• Diarrhea or constipation

• Nausea or vomiting

• Abdominal pain

• Flatulence (gas)

• Dizziness

• Dry mouth

• Rash or itching

• Upper respiratory infection (e.g., cough, sore throat, runny nose)

• Joint pain (arthralgia)

• Rare but serious: Low vitamin B12/magnesium, bone fractures, stomach polyps, QT prolongation (palpitations), or allergic reactions

Safety Advice

• Avoid or limit alcohol while taking Rabeprazole 20 mg (Enteric Coated) & Domperidone 30 mg (Sustained Release) Capsules IP, as it can worsen dehydration, increase acid production, and heighten side effects like dizziness or liver strain.

• Use during pregnancy only if benefits outweigh risks (FDA category B for rabeprazole, C for domperidone; limited data—consult your doctor). Not recommended during breastfeeding, as both may pass into breast milk and cause infant side effects like irritability or cardiac issues.

• Caution in patients with liver disease (rabeprazole/domperidone metabolism affected; dose adjustment or monitoring needed) or heart conditions (domperidone may prolong QT interval—avoid with other QT-prolonging drugs). Not for use in moderate-severe kidney impairment without advice.

• Long-term PPI use (>1 year) requires monitoring for nutrient deficiencies (e.g., B12, magnesium, calcium) and bone health; supplement if needed. Inform your doctor of all medications to avoid interactions (e.g., with warfarin, digoxin, or antifungals).

• Do not use for self-treatment of heartburn >14 days without diagnosis. Seek immediate help for severe abdominal pain, black stools, or difficulty swallowing.

Storage Conditions

• Store at temperatures below 30°C (86°F).

FAQs

What are Rabeprazole sodium and domperidone capsules?
They are used to treat GERD, acid reflux, heartburn, peptic ulcers, dyspepsia, and Zollinger-Ellison syndrome by reducing stomach acid and improving GI motility.

Do Rabeprazole & domperidone DSR capsules treat gastric bleeding?

No. Rabeprazole and domperidone prevent excess production of stomach acid, causing acid reflux and heartburn. If blood is coming in your stool or mucus, immediately contact the doctor.

Can rabeprazole and domperidone cause dry mouth?

Yes, Rabeprazole and domperidone tablet uses can cause dry mouth, and it is due to domperidone. In case you feel excessively thirsty, please increase your fluid intake and do frequent mouth rinses.

Do Rabeprazole sodium and domperidone capsules cause diarrhoea?

Diarrhoea might be a side-effect of Rabeprazole sodium and domperidone capsule. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or any other discomfort.

Can I lie down after having a meal?

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting on a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

What are the contraindications of Rabeprazole sodium and domperidone capsule?

Rabeprazole sodium and domperidone capsule is contraindicated in patients with a known hypersensitivity to domperidone or rabeprazole, or any other inactive ingredients of Rabeprazole 20mg (Enteric Coated) & Domperidone 30mg (Sustained Release) Capsule IP. Rabeprazole Capsule IP should be used with caution in patients with underlying liver or kidney disease.

Is it safe to use Rabeprazole 20mg (Enteric Coated) & Domperidone 30mg (Sustained Release) Capsule IP?

Yes, Rabeprazole 20mg (Enteric Coated) & Domperidone 30mg (Sustained Release) Capsule IP is safe for most patients. However, in some patients, it may cause common side effects such as stomach pain, diarrhoea, flatulence (gas), dryness in the mouth, headache, dizziness, and other uncommon and rare side effects. If these side effects persist or worsen, please consult your doctor.

What is the best time to take Rabeprazole 20mg (Enteric Coated) & Domperidone 30mg (Sustained Release) Capsule IP?

It is preferable to take Rabeprazole 20mg (Enteric Coated) & Domperidone 30mg (Sustained Release) Capsule IP on an empty stomach or before the first meal of the day.

Can the use of Rabeprazole 20mg (Enteric Coated) & Domperidone 30mg (Sustained Release) Capsule IP cause abnormal heartbeat?

Yes, Rabeprazole 20mg (Enteric Coated) & Domperidone 30mg (Sustained Release) Capsule IP may increase the risk of developing irregular heartbeat (serious arrhythmias). Although it is a serious side effect, it is extremely unlikely to occur. Patients aged above 60 years are at higher risk.