Product Description

Trypsin 48 mg, Bromelain 90 mg & Rutoside Trihydrate 100 mg Tablets IP is an enzyme-based combination medication with anti-inflammatory and mild analgesic properties. 

It is used as an adjunct to reduce pain, swelling, and inflammation associated with musculoskeletal injuries, post-surgical edema, and degenerative joint conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. 

Trypsin and bromelain are proteolytic enzymes that break down inflammatory proteins, while rutoside (a flavonoid antioxidant) strengthens blood vessels and reduces oxidative stress.

This formulation promotes faster recovery from trauma or surgery but is not a primary analgesic for general pain (e.g., not for fever, headaches, menstrual cramps, toothaches, earaches, or throat pain). Evidence for efficacy is supportive but limited compared to NSAIDs; use under medical supervision.

Avoid it if you have bleeding disorders, peptic ulcers, or hypersensitivity to enzymes/pineapple (bromelain source).

Uses

Trypsin, Bromelain & Rutoside Trihydrate Tablets IP are indicated for:

• Relief of inflammation, pain, and swelling in post-traumatic or post-surgical conditions (e.g., sprains, fractures, dental extractions)

• Adjunctive therapy in inflammatory/degenerative joint disorders (e.g., rheumatoid arthritis, osteoarthritis, ankylosing spondylitis)

• Reduction of edema and bruising in sports injuries or soft tissue trauma

How it works

Trypsin 48 mg, Bromelain 90 mg & Rutoside Trihydrate 100 mg Tablets combine two proteolytic enzymes and an antioxidant:

• Trypsin (48 mg): A serine protease enzyme that breaks down fibrin and inflammatory mediators (e.g., bradykinin), reducing edema and improving microcirculation by increasing blood supply to affected tissues.

• Bromelain (90 mg): Derived from pineapple stems, this mixture of proteases degrades proteins involved in inflammation, inhibits prostaglandin synthesis, and enhances the breakdown of necrotic tissue, thereby alleviating pain and swelling.

• Rutoside Trihydrate (100 mg): A bioflavonoid antioxidant that stabilizes capillary walls, prevents free radical damage, and reduces vascular permeability, further decreasing swelling and oxidative stress.

Together, they act as a potent anti-inflammatory adjunct by modulating the inflammatory cascade, promoting tissue repair, and easing pain without the GI risks of NSAIDs.

Benefits

This tablet combination provides relief from pain, inflammation, and swelling in trauma, surgery, or daily injuries, accelerating recovery by reducing bruising and edema (e.g., faster healing post-surgery). In joint conditions like rheumatoid arthritis or osteoarthritis, it supports mobility and reduces stiffness as an adjunct to standard therapy. The antioxidant properties protect against oxidative damage, making it useful for chronic inflammatory states. It is well-tolerated for short-term use, offering a non-steroidal option for patients intolerant to NSAIDs, though benefits are most evident when combined with rest, physiotherapy, or ice.

How to use

Take the medicine in the dose and duration as advised by the doctor. Swallow it as a whole. Do not chew, crush, or break it, with or without food, but it is better to take it at a fixed time.

Side Effects

Most side effects are mild and infrequent, resolving upon discontinuation. Common side effects (affecting <5% of patients) include:

• Nausea or stomach upset

• Diarrhea

• Headache

• Mild allergic reactions (e.g., rash, itching)

Safety Advice

• Alcohol: Interaction unknown, but alcohol may exacerbate GI irritation or bleeding risks; avoid or limit intake and consult your doctor.

• Pregnancy: Limited data available (equivalent to Category C—animal studies show no direct teratogenicity, but human safety is unestablished). Use only if benefits outweigh potential risks (e.g., severe post-surgical swelling); safer alternatives preferred. Inform your doctor if pregnant or planning pregnancy—effective contraception is advised during use.

• Breastfeeding: Limited data; enzymes may pass into milk and cause mild GI upset in infants. Use with caution or avoid; consult a doctor for alternatives and monitor the infant.

• Driving/Operating Machinery: Generally safe, but may cause mild dizziness or fatigue; use caution if affected.

Storage Conditions

• Store at a temperature below 30°C (86°F), in a cool, dry place away from direct sunlight, heat, and excessive moisture.

FAQs

Is trypsin a hormone?

No, Trypsin is not a hormone. It is an enzyme, a protein and an endopeptidase.

What is the recommended storage condition for Trypsin bromelain and rutoside trihydrate tablets?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, or other people.