Product Description

Citicoline 500 mg & Piracetam 800 mg Tablet IP is a fixed-dose combination of two nootropic agents for symptomatic management and neuroprotection in neurological disorders.

Citicoline supports neuronal membrane repair and neurotransmitter synthesis, while Piracetam enhances cerebral metabolism and synaptic plasticity. It is indicated for improving cognitive function in conditions like acute ischemic stroke recovery, traumatic brain injury (TBI), vascular dementia, and age-related cognitive decline. 

Not a cure; provides adjunctive support alongside rehabilitation. Prescription-only; evidence shows modest improvements (e.g., 10–20% in cognitive scores per trials like COBRALT for stroke).

Uses

• Adjunctive therapy in acute stroke or TBI to aid cognitive and motor recovery (e.g., reduce post-event deficits)

• Management of mild-to-moderate vascular dementia or age-related cognitive impairment (e.g., memory, attention)

• Supportive treatment in Parkinson's disease or Alzheimer's for symptom relief (off-label; not disease-modifying)

• Improvement of learning/memory in chronic cerebrovascular insufficiency or head injury sequelae

• Not indicated for severe dementia, psychiatric disorders, or as monotherapy; evaluate underlying cause first

How it works

This combination provides synergistic neuroprotection and cognitive enhancement through complementary mechanisms:

• Citicoline (500 mg): An exogenous precursor to phosphatidylcholine (major neuronal membrane phospholipid) that stabilizes cell membranes, reduces phospholipase A2 activity, and promotes repair after ischemia/injury. It boosts acetylcholine and dopamine synthesis, enhances cerebral blood flow (via vasodilation), and improves energy metabolism (ATP production), ensuring better oxygen/nutrient delivery to brain tissue. Effects onset in 1–2 weeks.

• Piracetam (800 mg): A racetam derivative that modulates AMPA glutamate receptors, increasing neuronal excitability and synaptic plasticity without direct neurotransmitter release. It improves membrane fluidity, enhances interhemispheric communication (via corpus callosum), and protects against hypoxia by optimizing glucose utilization and microcirculation. Effects build over 2–4 weeks.

Together, they support brain resilience, with Citicoline focusing on repair and Piracetam on function, aiding recovery in hypoxic/ischemic events.

Benefits

• Enhances cognition: Improves memory, attention, and executive function (e.g., MMSE score +2–4 points in vascular dementia trials), beneficial for post-stroke or age-related decline.

• Neuroprotection: Reduces infarct size (up to 20% in animal models) and neuronal apoptosis in stroke/TBI, accelerating functional recovery (e.g., faster ADL independence).

• Improves quality of life: Boosts mental clarity, concentration, and daily activities; Piracetam aids learning processes, while Citicoline maintains membrane integrity for long-term brain health.

• Well-tolerated adjunct: Non-sedating at therapeutic doses; suitable for the elderly with minimal cardiovascular impact.

How to use

Swallow the tablets whole with a full glass of water. Do not crush, break, or chew them. Take the tablets at the same time each day to maintain consistent drug levels. It is often recommended to take them after a meal to reduce the risk of stomach upset. For many neurological conditions, this medication is part of a long-term treatment plan. Do not take more or less, or for longer than recommended, and do not stop taking it abruptly without consulting your doctor. If you forget a dose, take it as soon as you remember. Inform your doctor if you have a history of allergies to Citicoline, Piracetam, or any of the ingredients.

Side Effects

Common side effects (mild, transient; <5% incidence):

• Central nervous system: Insomnia, nervousness, agitation, drowsiness, headache, dizziness

• Gastrointestinal: Nausea, vomiting, diarrhea, constipation, abdominal pain, stomach upset

Less common/rare but serious side effects (seek immediate medical attention):

• Weight changes: Gain (Piracetam-related, due to fluid retention)

• Allergic: Rash, pruritus, urticaria

• Psychiatric: Depression, anxiety, irritability (rare)

• Other: Hyperactivity (in children, if used), elevated liver enzymes (monitor LFTs)

Side effects often resolve with dose adjustment; report persistent symptoms.

Safety Advice

Inform your doctor if you have a history of severe kidney disease and provide a complete list of all medications, supplements, and herbal products you are taking, as piracetam is cleared by the kidneys and may require a dosage adjustment. Also, mention any history of epilepsy, bleeding disorders, or thyroid issues. Piracetam can interact with blood thinners (anticoagulants) and thyroid hormones. Do not take this medication if you are pregnant, planning to become pregnant, or breastfeeding without consulting your doctor. The effects on the fetus and infant are not well-established.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

Is this medication a cure for cognitive decline?

No, it is a management tool that helps improve symptoms and protect brain function, but it does not cure the underlying condition.

Is this medication for everyone?

No, it is a prescription medication and is not suitable for individuals with severe kidney disease, bleeding disorders, or specific allergies.

How should this medication be taken?

Take the tablets as prescribed by a doctor, usually two to three times a day, with or after a meal. Swallow them whole with water.

Can the medication be stopped if symptoms improve?

Do not stop taking the medication suddenly without consulting a doctor, as abrupt cessation can cause withdrawal symptoms.

Can this medication cause weight gain?

Weight gain is a possible but less common side effect associated with Piracetam.

Does it increase the risk of bleeding?

Piracetam has a mild blood-thinning effect. Use with caution if taking blood thinners and be alert for unusual bleeding or bruising.

Are there any drug interactions?

Yes, Piracetam can interact with blood thinners and thyroid hormones. Inform the doctor about all medications and supplements.

Can this medication affect epilepsy?

Piracetam can potentially lower the seizure threshold. Inform the doctor if you have a history of epilepsy.

Can this medication be used for children?

The safety and effectiveness of this combination in children have not been established.

What about driving or operating machinery?

Exercise caution until you know how the medication affects you, as it can cause drowsiness or dizziness.

How should this medication be stored?

Store the tablets in a cool, dry place, away from sunlight and moisture.