Product Description

Dapagliflozin 10 mg and Metformin Hydrochloride 1000 mg Extended Release Tablet belong to the class of antidiabetic drugs and are primarily used to treat type 2 diabetes mellitus in conjunction with a proper diet and exercise. This combination tablet also helps reduce the risk of hospitalization for heart failure in patients with type 2 diabetes and established cardiovascular disease. Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar levels. Type 2 diabetes occurs when the body becomes resistant to insulin—a hormone produced by the beta cells of the pancreas—or when the pancreas produces insufficient insulin. This impairs the breakdown of glucose for energy. Dapagliflozin and Metformin combination tablets are not indicated for use in type 1 diabetes.

Uses

• Treatment of Type 2 Diabetes Mellitus

• Reduction of risk of hospitalization for heart failure in patients with type 2 diabetes and cardiovascular disease

How it works

Dapagliflozin 10 mg and Metformin Hydrochloride 1000 mg Tablet combines two mechanisms to control blood sugar levels:

• Metformin decreases glucose production in the liver and improves the body’s sensitivity to insulin, helping cells absorb glucose more effectively without increasing insulin secretion.

• Dapagliflozin inhibits SGLT2 in the kidneys, reducing glucose reabsorption and increasing urinary glucose excretion, thereby lowering blood glucose levels.

Benefits

• Effectively lowers blood sugar levels in patients with type 2 diabetes mellitus.

• Does not cause hypoglycemia when used alone, as Metformin does not stimulate insulin secretion.

• Improves insulin sensitivity, especially beneficial in obese patients.

• Reduces the risk of hospitalization for heart failure in patients with type 2 diabetes and cardiovascular disease.

• It can be used alone or in combination with other antidiabetic medications, alongside diet and exercise, to achieve optimal blood glucose control. 

How to use

• Swallow the tablet whole with water; do not crush, break, or chew.

• Take preferably with meals to reduce gastrointestinal side effects and minimize the risk of hypoglycemia.

• Your doctor may start treatment with a low dose and gradually increase it to achieve the desired blood glucose control.

Side Effects

Common side effects may include:

• Nausea

• Vomiting

• Diarrhea

• Headache

• Weakness

• Runny nose

• Genital infections (e.g., yeast infections)

• Dizziness

• Taste changes

• Sore throat

Safety Advice

• Avoid alcohol consumption as it may increase the risk of lactic acidosis and hypoglycemia.

• Dapagliflozin is not recommended during the second and third trimesters of pregnancy. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

• Inform your doctor about any history of kidney, liver, or heart disease, breathing problems, blood disorders (such as anemia or vitamin B12 deficiency), dehydration, low blood pressure, pancreatic issues, or recent surgery.

• This medication is contraindicated in patients with severe renal impairment and metabolic acidosis, including diabetic ketoacidosis.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

What is Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet used for?

Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet belongs to the class of 'antidiabetic drugs', primarily used to treat type 2 diabetes mellitus with a proper diet and exercise. Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet also lowers the risk of heart failure in type 2 diabetic patients with heart disease.

How does Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet work?

Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet contains two antidiabetic medicines: Metformin and Dapagliflozin. These drugs lower the blood sugar levels in type 2 diabetes mellitus by eliminating excess sugar through urine and also by increasing the activity of insulin.

Does Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet lower blood sugar levels?

Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet may cause low blood sugar levels (hypoglycaemia) and can make you hungry, dizzy, irritable, confused, anxious, or shaky. Hence, it is advised to take Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet with a meal. To immediately treat hypoglycaemia, it is advised to eat or drink fast-acting sugar sources like fruit juices, hard candy, raisins, or non-diet soda.

Can I use Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet with other diabetic medications?

Your doctor may advise Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet with or without other medications to control your blood sugar levels. It is recommended to follow a balanced diet and regular exercise routine to effectively manage blood sugar levels while taking Dapagliflozin 10mg and Metformin Hydrochloride 1000mg Tablet, with or without other medications. other antidiabetic drugs.

In which conditions should I stay cautious while using Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet?

Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet should be used with caution in heart, kidney, or liver diseases, breathing problems (asthma, obstructive lung disease), blood disorders (anaemia, vitamin B12 deficiency), Dehydration, alcohol consumption, low blood pressure, pancreatic issues or surgery, and genital yeast infections. Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet is contraindicated in patients with severe renal impairment and metabolic acidosis/diabetic ketoacidosis.

What precautions do I need to take while using Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet?

While using Dapagliflozin 10mg & Metformin Hydrochloride 1000mg Tablet, if you experience vomiting, stomach/abdominal pain, muscle cramps, a sick feeling, severe tiredness, difficulty in breathing, or reduced body temperature and heartbeat, it is important to seek immediate medical help since these are the symptoms of lactic acidosis. Lactic acidosis is a rare but serious complication caused by the accumulation of metformin. It is a medical emergency and needs immediate treatment. Please consult your doctor for further information.