Product Description

Dapagliflozin 10mg & Metformin Hydrochloride Extended Release 500mg Tablet is a combination antidiabetic medication primarily used to treat type 2 diabetes mellitus alongside a proper diet and exercise regimen. This combination helps control blood sugar levels and reduces the risk of heart failure in patients with type 2 diabetes and established cardiovascular disease. Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin resistance or insufficient insulin production by pancreatic beta cells. This medication is not indicated for type 1 diabetes mellitus or diabetic ketoacidosis.

Uses

• Treatment of type 2 diabetes mellitus to improve glycemic control.

• Reduction of the risk of hospitalization for heart failure in patients with type 2 diabetes and cardiovascular disease.

How it works

• Metformin decreases glucose production in the liver and enhances the body's response to insulin, improving glucose uptake by tissues.

• Dapagliflozin blocks SGLT2 in the kidneys, reducing glucose reabsorption and increasing urinary glucose excretion, thereby lowering blood sugar levels.

Benefits

• Effective blood sugar control in type 2 diabetes mellitus.

• Does not cause hypoglycemia when used alone, as it does not stimulate insulin secretion.

• Reduces the risk of heart failure-related hospitalization in patients with type 2 diabetes and heart disease.

• It may be used alone or in combination with other antidiabetic medications, along with diet and exercise.

How to use

• Swallow the tablet whole with water; do not crush, break, or chew.

• Take the tablet preferably with meals to reduce gastrointestinal side effects.

• Your doctor will start you on a low dose and may gradually increase it to achieve optimal blood glucose control.

Side Effects

Common side effects may include:

• Nausea

• Vomiting

• Diarrhea

• Headache

• Weakness

• Dizziness

• Runny nose

• Sore throat

• Taste changes

• Genital yeast infections (due to increased glucose in urine)

Safety Advice

• Avoid alcohol consumption, as it may increase the risk of lactic acidosis and hypoglycemia.

• Dapagliflozin is not recommended during the second and third trimesters of pregnancy. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

• Inform your doctor if you have kidney, liver, or heart disease, or if you experience symptoms such as vomiting, abdominal pain, muscle cramps, severe tiredness, difficulty breathing, or irregular heartbeat, as these may indicate serious complications.

• Regular monitoring of kidney function is essential during treatment.

• Stay hydrated to reduce the risk of dehydration and low blood pressure.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

What is Dapagliflozin 10mg & Metformin Hydrochloride 500mg Tablet used for?

It is used to treat type 2 diabetes mellitus by controlling blood sugar levels and reducing the risk of heart failure in patients with heart disease.

How does Dapagliflozin 10mg & Metformin Hydrochloride 500mg Tablet work?

Metformin reduces glucose production in the liver and improves insulin sensitivity, while dapagliflozin increases glucose excretion through urine by inhibiting kidney glucose reabsorption.

Does Dapagliflozin 10mg & Metformin Hydrochloride 500mg Tablet lower blood sugar levels?

When used alone, the risk of hypoglycemia is low. However, the risk increases if combined with insulin or other antidiabetic drugs that increase insulin secretion. Take medication with meals to reduce this risk.

Can I use Dapagliflozin 10mg & Metformin Hydrochloride 500mg Tablet with other diabetic medications?

Yes, your doctor may prescribe it alone or with other antidiabetic medications to achieve better blood sugar control.

In which conditions should I stay cautious while using Dapagliflozin 10mg & Metformin Hydrochloride 500mg Tablet?

Dapagliflozin 10mg & Metformin Hydrochloride 500mg Tablet should be used with caution in heart, kidney, or liver diseases, breathing problems (asthma, obstructive lung disease), blood disorders (anaemia, vitamin B12 deficiency), Dehydration, alcohol consumption, low blood pressure, pancreatic issues or surgery, and genital yeast infections. Dapagliflozin 10mg & Metformin Hydrochloride 500mg Tablet is contraindicated in patients with severe renal impairment and metabolic acidosis/diabetic ketoacidosis.

What precautions do I need to take while using Dapagliflozin 10mg & Metformin Hydrochloride 500mg Tablet?

Inform your doctor if you have kidney, liver, or heart problems, or if you experience symptoms like severe fatigue, abdominal pain, vomiting, or irregular heartbeat. Avoid alcohol and maintain adequate hydration.