Product Description

Dapagliflozin 10 mg & Sitagliptin 100 mg Tablets IP are used to treat type 2 diabetes mellitus. Type 2 diabetes mellitus, also known as non-insulin-dependent diabetes, is a condition characterized by elevated blood glucose levels due to insufficient insulin production, insulin resistance, or both.

Uses

Dapagliflozin and Sitagliptin tablets are used to treat Type 2 diabetes mellitus.

How it works

This tablet contains two antidiabetic medicines: Dapagliflozin (an SGLT2 inhibitor) and Sitagliptin (a DPP-4 inhibitor).

• Dapagliflozin reduces blood glucose by promoting the excretion of excess glucose through urine.

• Sitagliptin increases insulin secretion and decreases glucagon release, reducing hepatic glucose production.

• Together, they help control blood sugar levels effectively.

Benefits

• Effectively manages type 2 diabetes mellitus by lowering blood glucose levels.

• Dapagliflozin promotes urinary excretion of excess sugar, while Sitagliptin enhances insulin release and reduces glucagon activity.

• Used in combination with diet and exercise to improve glycemic control.

How to use

• Swallow the tablet whole with a glass of water, with or without food; do not break, chew, or crush it.

• Take as prescribed by your doctor, usually once daily. Do not skip doses or stop without medical advice.

Side Effects

Common side effects may include:

• Stomach upset

• Hypoglycaemia (low blood sugar levels)

• Nausea

• Vomiting

• Diarrhoea

• Headache

• Constipation

• Dizziness

• Runny nose

• Sore throat

Serious side effects (seek immediate medical help):

• Genital or urinary tract infections (more common with Dapagliflozin)

• Pancreatitis (rare, with Sitagliptin)

• Volume depletion or hypotension (with Dapagliflozin)

• Euglycemic diabetic ketoacidosis (DKA; symptoms: nausea, abdominal pain, fruity breath)

• Severe allergic reactions (e.g., rash, swelling)

Report any unusual symptoms to your doctor promptly.

Safety Advice

• Alcohol: Avoid alcohol, as it may cause serious side effects like increased hypoglycemia or lactic acidosis risk.

• Pregnancy and Breastfeeding: Inform your doctor if pregnant or planning pregnancy. Dapagliflozin is not recommended in the second/third trimester; use only if the benefits outweigh risks.

• Kidney/Liver Conditions: Use with caution; inform your doctor of any renal or hepatic impairment, as dose adjustments may be needed.

• Contraindications: Do not use if you have severe renal impairment, hepatic disease, a history of pancreatitis, diabetic ketoacidosis, or hypersensitivity to the ingredients. Not for type 1 diabetes.

• Drug Interactions: Inform your doctor about medications like diuretics (increase DKA risk), insulin, corticosteroids, or CYP inducers/inhibitors, as they may affect efficacy or side effects.

• Monitoring: Regular blood glucose, kidney function, and ketone monitoring are recommended. Watch for signs of infection or dehydration.

• Consult your doctor for any underlying conditions or if you are elderly.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

What is the use of Dapagliflozin 10 mg & Sitagliptin IP 100 mg Tablet?

Dapagliflozin 10 mg and Sitagliptin IP 100 mg tablets are prescribed for the treatment of type 2 diabetes mellitus. Type 2 diabetes mellitus, also referred to as non-insulin-dependent or adult-onset diabetes, is a condition characterized by elevated blood glucose levels resulting from insufficient insulin, insulin resistance, or a combination of both.

What are the causes of diabetes?

Common causes of diabetes include diets low in fiber, high in fat or sugar, obesity, smoking, stress, physical inactivity, aging, genetic predisposition, and certain medical conditions.

How does Dapagliflozin 10 mg & Sitagliptin IP 100 mg Tablet work?

Dapagliflozin 10 mg and Sitagliptin IP 100 mg tablets are a combination therapy for type 2 diabetes mellitus. Sitagliptin boosts glucose-dependent insulin secretion, lowering both fasting and post-meal blood sugar levels. Dapagliflozin reduces blood glucose by increasing urinary glucose excretion. Additionally, sitagliptin decreases liver glucose production by elevating insulin levels and reducing glucagon levels, a hormone that increases blood glucose.