Product Description

Dapagliflozin 5 mg & Sitagliptin 50 mg Tablets IP are used to treat type 2 diabetes mellitus. Type 2 diabetes mellitus, also known as non-insulin-dependent diabetes, is a condition characterized by elevated blood glucose levels due to insufficient insulin production, insulin resistance, or both.

Uses

Dapagliflozin and Sitagliptin tablets are used to treat Type 2 diabetes mellitus.

How it works

This tablet contains two antidiabetic medicines: Dapagliflozin (an SGLT2 inhibitor) and Sitagliptin (a DPP-4 inhibitor).

• Dapagliflozin reduces blood glucose by promoting the excretion of excess glucose through urine.

• Sitagliptin increases insulin secretion and decreases glucagon release, reducing hepatic glucose production.

• Together, they help control blood sugar levels effectively.

Benefits

• Effectively manages type 2 diabetes mellitus by lowering blood glucose levels.

• Dapagliflozin promotes urinary excretion of excess sugar, while Sitagliptin enhances insulin release and reduces glucagon activity.

• Used in combination with diet and exercise to improve glycemic control.

How to use

• Swallow the tablet whole with a glass of water, with or without food; do not break, chew, or crush it.

• Take as prescribed by your doctor, usually once daily. Do not skip doses or stop without medical advice.

Side Effects

Common side effects may include:

• Stomach upset

• Hypoglycaemia (low blood sugar levels)

• Nausea

• Vomiting

• Diarrhoea

• Headache

• Constipation

• Dizziness

• Runny nose

• Sore throat

Report any unusual symptoms to your doctor promptly.

Safety Advice

• Alcohol: Avoid alcohol, as it may cause serious side effects like increased hypoglycemia or lactic acidosis risk.

• Pregnancy and Breastfeeding: Inform your doctor if pregnant or planning pregnancy. Dapagliflozin is not recommended in the second/third trimester; use only if the benefits outweigh risks.

• Kidney/Liver Conditions: Use with caution; inform your doctor of any renal or hepatic impairment, as dose adjustments may be needed.

• Contraindications: Do not use if you have severe renal impairment, hepatic disease, a history of pancreatitis, diabetic ketoacidosis, or hypersensitivity to the ingredients. Not for type 1 diabetes.

• Drug Interactions: Inform your doctor about medications like diuretics (increase DKA risk), insulin, corticosteroids, or CYP inducers/inhibitors, as they may affect efficacy or side effects.

• Monitoring: Regular blood glucose, kidney function, and ketone monitoring are recommended. Watch for signs of infection or dehydration.

• Consult your doctor for any underlying conditions or if you are elderly.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

What is the use of Dapagliflozin 5 mg & Sitagliptin 50 mg Tablets IP?

Dapagliflozin 5 mg & Sitagliptin 50 mg Tablets IP are used to treat type 2 diabetes mellitus. Type 2 diabetes mellitus, also referred to as non-insulin-dependent or adult-onset diabetes, is a condition characterized by elevated blood glucose levels caused by insufficient insulin, insulin resistance, or a combination of both.

What are the causes of diabetes?

Common causes of diabetes include low-fiber diets, high-fat or sugary diets, obesity, smoking, stress, physical inactivity, aging, genetic factors, and certain medical conditions.

How does Dapagliflozin 5 mg & Sitagliptin 50 mg Tablets IP work?

Dapagliflozin 5 mg & Sitagliptin 50 mg Tablets IP is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin reduces blood glucose by enhancing urinary glucose excretion. Sitagliptin lowers blood glucose by boosting insulin levels and suppressing glucagon (a hormone that increases blood glucose), thereby reducing liver glucose production.