Product Description

Etoricoxib Tablets IP 120 mg belong to a class of medications called selective cyclooxygenase-2 (COX-2) inhibitors, a subclass of non-steroidal anti-inflammatory drugs (NSAIDs), used to relieve pain, swelling, and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis in adults and adolescents aged 16 years and older. It is also indicated for short-term relief of moderate pain, such as following dental surgery (up to 3 days). Osteoarthritis is a degenerative joint disease where cartilage breakdown leads to pain and stiffness.

Rheumatoid arthritis is an autoimmune disorder causing chronic joint inflammation. Ankylosing spondylitis involves inflammation of the spine and sacroiliac joints, leading to stiffness and fusion. Gouty arthritis results from uric acid crystal deposition in joints, causing acute painful flares.

Etoricoxib works by selectively inhibiting the COX-2 enzyme, which reduces the production of prostaglandins—chemical mediators responsible for pain, fever, and inflammation at sites of injury or disease—while sparing COX-1 (which protects the stomach lining), potentially lowering the risk of gastrointestinal ulcers compared to non-selective NSAIDs like ibuprofen or aspirin. However, it still carries cardiovascular, GI, and renal risks, especially with long-term use.

Uses

• Relief of pain and inflammation in osteoarthritis (60-90 mg once daily)

• Treatment of rheumatoid arthritis (90 mg once daily)

• Management of ankylosing spondylitis (90 mg once daily)

• Short-term treatment of acute gouty arthritis (120 mg once daily for up to 8 days; 90 mg may be used off-label)

• Short-term relief of moderate acute pain (e.g., post-dental surgery; 120 mg once daily for up to 3 days)

How it works

Etoricoxib Tablets IP 120 mg contain etoricoxib, a selective COX-2 inhibitor that blocks the COX-2 enzyme at sites of inflammation, preventing the conversion of arachidonic acid to prostaglandins. Prostaglandins sensitize pain receptors, promote swelling, and cause fever. By targeting COX-2 (induced during inflammation) more than COX-1 (constitutive, protects GI mucosa and kidneys), it reduces pain and inflammation with a potentially lower risk of stomach ulcers than non-selective NSAIDs. Effects begin within hours and last 24 hours, allowing once-daily dosing.

Benefits

• Provides targeted relief from joint pain, stiffness, and swelling in chronic inflammatory conditions like rheumatoid arthritis or ankylosing spondylitis, improving mobility and quality of life

• Effective for acute gout flares, reducing severe pain and inflammation faster than some alternatives

• Lower incidence of gastrointestinal side effects (e.g., ulcers) compared to traditional NSAIDs, making it suitable for patients at GI risk

• Once-daily dosing enhances adherence; useful short-term for post-surgical pain without opioids

• Does not significantly affect platelet function (unlike aspirin), reducing bleeding risk in some scenarios

How to use

• Swallow the tablet whole with a glass of water; do not crush, break, or chew it.

• Take once daily, with or without food, at the same time each day for consistent effects.

• For acute pain (e.g., gout or dental), use the lowest effective dose for the shortest duration (e.g., 3-8 days).

• Do not exceed the prescribed dose or duration; combine with non-drug measures like rest, ice, or physical therapy.

Side Effects

Etoricoxib side effects

• Stomach pain or abdominal discomfort

• Headache

• Dizziness

• Swelling of legs or feet (edema due to fluid retention)

• High blood pressure (hypertension)

• Nausea or vomiting

• Diarrhea or constipation

• Indigestion (dyspepsia) or heartburn

• Flatulence (gas)

• Gastritis or esophagitis (inflammation of stomach/esophagus)

• Fatigue or weakness

• Flu-like symptoms (fever, sore throat, cough)

• Palpitations or shortness of breath

• Mouth ulcers

• Abnormal liver function tests

• Rare but serious: Allergic reactions (rash, swelling, anaphylaxis), GI bleeding/ulcers, heart attack/stroke, kidney failure

Safety Advice

• Limit or avoid alcohol while taking Etoricoxib Tablets IP 120 mg, as it increases the risk of stomach bleeding, liver damage, and cardiovascular events.

• Contraindicated in pregnancy (especially 3rd trimester due to fetal risks; category C—consult your doctor if planning pregnancy). Not recommended during breastfeeding, as it may affect the infant (e.g., rash or kidney issues).

• Use with caution in liver impairment (mild: max 60 mg/day; moderate: max 30 mg/day; severe: avoid); monitor liver function tests. Dose adjustment or avoidance needed in kidney disease (e.g., CrCl <30 mL/min). Elderly patients (>65 years) are at higher risk for side effects—use lowest dose.

• Monitor blood pressure regularly, as it may cause fluid retention and hypertension. Avoid in active inflammatory bowel disease or dehydration. Inform your doctor of all medications (e.g., avoid with diuretics, ACE inhibitors, or other NSAIDs due to interaction risks).

• Stop immediately if signs of heart issues (chest pain, shortness of breath), severe GI symptoms (black stools, vomiting blood), or allergic reactions occur. Not for long-term use without specialist oversight due to CV risks.

Storage Conditions

• Store at temperatures below 30°C (86°F).

FAQs

What is the Etoricoxib uses for?

Etoricoxib Tablets is used to treat pain, swelling and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and gout in people greater than 16 years of age. Besides this, it is also used to treat moderate pain after dental surgery.

How does Etoricoxib 120 mg work?

Etoricoxib Tablets IP 120 mg contains etoricoxib, which is a non-steroidal anti-inflammatory drug (NSAID). It is a COX-2 inhibitor. COX-2 enzyme produces prostaglandins that cause pain, swelling and inflammation.

Can I use Etoricoxib Tablets for long-term pain relief?

You should not take Etoricoxib 120 mg for the longer term, especially in higher doses, as it increases the risk of heart attack and stroke.

Can I drive after taking Etoricoxib Tablets IP 120 mg?

Etoricoxib uses may cause dizziness. So, driving or operating heavy machinery is not advisable after taking the pills. 

Can Etoricoxib Tablets  be used in children?

Etoricoxib 120 mg is not recommended for use in children below 16 years of age.

Do Etoricoxib Tablets IP 120 mg increase blood pressure?

Etoricoxib dose may increase blood pressure, especially in high doses. It should not be given to patients with uncontrolled blood pressure, heart problems, or recent heart surgeries.

Is Etoricoxib Tablets IP 120 mg a painkiller?

Etoricoxib 120 mg is a pain killer that helps to reduce pain and inflammation in joint disorders. However, taking it without a doctor's advice is not recommended.

What should I consult with the doctor about while taking Etoricoxib Tablets?

Talk to your healthcare professional before Etoricoxib if you have any underlying medical conditions or are taking any medications. Also, ask for advice about precautions and limitations.

Can I take Aspirin when I am taking Etoricoxib Tablets IP 120 mg ?

The risk of stomach ulcers is greater if you take Etoricoxib 120 mg with aspirin. So, exercise caution.

How long do I need to take Etoricoxib Tablets?

The time it takes to see results, may vary depending on many factors. It's important to follow the recommended dosage and treatment regimen and to consult with a healthcare professional for ongoing monitoring.

How should Etoricoxib Tablets IP 120 mg be taken?

Etoricoxib uses orally. Swallow the tablet as a whole with a glass of water. Do not crush, chew, or break it. Take it at the same time every day for effective results.

Does Etoricoxib Tablets IP 120 mg cause sleepiness?

Dizziness and sleepiness have been reported in some patients taking Etoricoxib Tablets IP 120 mg . Do not drive if you experience dizziness or sleepiness.

Does Etoricoxib Tablets IP 120 mg have any effect on birth control pills?

Etoricoxib Tablets IP 120 mg may increase the incidence of adverse events associated with oral contraceptives.

How long does Etoricoxib Tablets IP 120 mg take to work?

Etoricoxib Tablets IP 120 mg contains Etoricoxib, is a COX-2 inhibitor with an onset of action at 20-30 minutes, with a duration of action of? 24 hours.

Is Etoricoxib Tablets IP 120 mg a painkiller?

Yes, Etoricoxib Tablets IP 120 mg contains etoricoxib, which is a non-steroidal anti-inflammatory drug (NSAID) or painkiller.