Product Description

Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet is used in the treatment of Type 2 diabetes mellitus. Type 2 diabetes mellitus is a chronic condition characterized by elevated blood sugar levels due to insufficient insulin production or insulin resistance. This combination helps control blood sugar when single or dual therapies are inadequate.

Uses

Treatment of Type 2 Diabetes Mellitus.

How it works

This tablet contains three antidiabetic medicines: Glibenclamide (a sulfonylurea), Metformin (a biguanide), and Pioglitazone (a thiazolidinedione).

• Glibenclamide stimulates the pancreas to produce more insulin.

• Metformin reduces glucose production in the liver and decreases intestinal glucose absorption.

• Pioglitazone lowers liver glucose release and enhances insulin sensitivity in muscle and fat tissues.

• Together, they provide comprehensive blood sugar control.

Benefits

• Effectively treats type 2 diabetes mellitus by improving insulin production, reducing glucose production, and enhancing insulin sensitivity.

• Helps lower postprandial blood sugar levels alongside diet and exercise.

• Used when monotherapy or dual therapy fails to control blood sugar.

How to use

• Take the tablet whole with water; do not crush, break, or chew it.

• Take at a fixed time every day, with food, as prescribed by your doctor to prevent hypoglycemia.

• Your doctor may adjust the dose based on your blood sugar levels. Do not skip doses.

Side Effects

Common side effects may include:

• Nausea

• Vomiting

• Diarrhoea

• Stomach ache

• Respiratory infection

• Weight gain

• Numbness

• Vision problems

Serious side effects (seek immediate medical help):

• Hypoglycemia (low blood sugar; symptoms: sweating, confusion, rapid heartbeat)

• Lactic acidosis (with Metformin; symptoms: muscle pain, difficulty breathing, abdominal pain)

• Edema or fluid retention (with Pioglitazone)

• Fractures or bone issues (with Pioglitazone)

• Bladder cancer risk (with Pioglitazone)

• Heart failure exacerbation (with Pioglitazone)

Report any persistent or severe symptoms to your doctor.

Safety Advice

• Alcohol: Avoid consuming, as it can raise the risk of side effects and worsen the condition.

• Pregnancy and Breastfeeding: Category C drug; may cause harmful effects to the unborn baby. Use only if the benefits outweigh the risks. Consult your doctor. Not recommended while breastfeeding.

• Liver/Kidney Conditions: Use with caution; inform your doctor of liver or kidney issues, as dose adjustments may be needed.

• Contraindications: Do not use if you have type 1 diabetes, diabetic ketoacidosis, severe renal/hepatic impairment, bladder cancer history, or hypersensitivity to the ingredients.

• Drug Interactions: Inform your doctor about medications like insulin, NSAIDs, diuretics, or CYP2C8 inducers/inhibitors, as they may affect efficacy or increase risks.

• Monitoring: Regular blood glucose, liver function, weight, and edema checks are advised. Monitor for signs of hypoglycemia or lactic acidosis.

• Consult your doctor if you have heart disease or are elderly.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

What is the use of Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet?

Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet is used in the treatment of Type 2 diabetes mellitus.

How does Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet work?

Glibenclamide 5 mg & Metformin 500 mg Pioglitazone 15 mg Tablet is a combination of three antidiabetic medicines, Glibenclamide, Metformin, and Pioglitazone. It works by increasing the production of insulin, helping to restore your body's appropriate response to insulin, and thereby lowering your elevated blood sugar levels.

Can Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet be used to treat type 1 diabetes?

Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet is used to treat type 2 diabetes. It is not recommended for the treatment of type 1 diabetes.

What is hypoglycemia? Does Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet cause hypoglycemia?

Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet may cause hypoglycemia (low blood sugar levels). Hypoglycemia can occur if you miss or delay your food, drink alcohol, intense exercise, or take other antidiabetic medicines along with this medicine. So, take your medicine as advised by your doctor to avoid any unwanted effects of this medicine.

What should I do if my blood sugar level suddenly decreases?

If you notice your blood sugar levels dropping, take glucose tablets or eat some chocolate right away. This will help to increase your sugar levels instantly. Therefore, it is recommended to always keep glucose tablets or sugar candies with you.

What will be the consequences if I stop Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet on my own?

Stopping Glibenclamide 5 mg & Metformin 500 mg Pioglitazone 15 mg Tablet may cause a rise in blood sugar levels. Therefore, continue taking Glibenclamide 5 mg & Metformin 500 mg Pioglitazone 15 mg Tablet as directed, even if your symptoms improve.

What should be discussed with my healthcare provider before I start Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet?

Before starting Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet, share your medical history, including any existing conditions or allergies. If you're pregnant or breastfeeding, be sure to let your doctor know. Inform the doctor if you are taking any other medications, supplements, or herbal products.

Does Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet make you tired and drowsy?

Some individuals may feel tired and drowsy after taking Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet. Only drive or operate machinery when you feel fully alert. If you're experiencing any of these symptoms persistently, it's crucial to consult your doctor.

Is Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet a steroid?

No, Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet does not contain steroids. Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet is a medication specifically designed to manage type 2 diabetes. It's a combination therapy that helps regulate blood sugar levels.

How long does it take for Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet to work?

Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet may take around 2-3 months to reach its full effect, but you may start noticing improvements in your blood sugar control within the first few weeks.

Can I take Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet, and Fexofenadine together?

It is generally safe to take Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet, and Fexofenadine together if it is prescribed by your doctor. Fexofenadine is an antihistamine used to treat allergies, and it doesn't typically interact with Glibenclamide 5 mg & Metformin 500 mg Pioglitazone 15 mg Tablet. However, it's always best to consult your doctor or pharmacist before combining any medications.

For how long should I continue Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet?

You should take Glibenclamide 5 mg, Metformin 500 mg & Pioglitazone 15 mg Tablet for as long as it has been prescribed by the doctor to help control your blood sugar levels. This medication is usually taken for a long time, potentially many years, to manage type 2 diabetes effectively.