Product Description

Lamotrigine Dispersible Tablets IP 50 mg belong to a class of medications called anticonvulsants (anti-epileptics), primarily used to treat epilepsy (recurrent seizures) in adults and children. They are also indicated for bipolar I disorder (maintenance treatment to delay mood episodes, particularly depressive phases). Epilepsy involves abnormal electrical activity in the brain, leading to seizures that can cause convulsions, loss of consciousness, or altered behavior. Bipolar disorder is a chronic mood disorder characterized by extreme shifts between manic (elevated mood/energy) and depressive episodes, affecting daily functioning.

Lamotrigine works by stabilizing neuronal membranes through inhibition of voltage-sensitive sodium channels, reducing excessive glutamate release (an excitatory neurotransmitter), and modulating other ion channels to decrease abnormal electrical firing in the brain. This helps control seizures and stabilize mood swings without significant sedation.

Uses

• Treatment of partial seizures, generalized tonic-clonic seizures, and Lennox-Gastaut syndrome in epilepsy

• Maintenance therapy for bipolar I disorder to prevent depressive and manic episodes

How it works

Lamotrigine Dispersible Tablets IP 50 mg contain lamotrigine, which inhibits voltage-gated sodium channels in the brain, prolonging the inactive state of neurons and reducing the release of excitatory neurotransmitters like glutamate. This dampens excessive electrical activity and hypersynchronous firing that cause seizures. In bipolar disorder, it stabilizes mood by modulating neuronal excitability in limbic and cortical regions, helping prevent depressive relapses more effectively than manic ones. The dispersible form allows quick dissolution for easier administration, especially in patients with swallowing difficulties.

Benefits

• Effectively controls various seizure types, reducing frequency and severity to improve quality of life and independence

• Provides mood stabilization in bipolar disorder, particularly delaying depressive episodes, with a favorable side-effect profile (less weight gain or cognitive impairment than other mood stabilizers)

• Dispersible formulation is convenient for children, elderly, or those with dysphagia, dissolving rapidly in water without altering efficacy

• Long-term use supports seizure freedom in up to 50-70% of patients as adjunctive therapy

• Minimal impact on daily activities compared to sedating anticonvulsants

How to use

• For dispersible tablets: Place the tablet in a small amount of water (e.g., 1-2 teaspoons) or suitable liquid (check label); stir until fully dispersed (it may not dissolve completely), then swallow immediately. Do not chew or swallow whole.

• Take with or without food, usually once or twice daily as prescribed; maintain consistent timing for steady blood levels.

• Dosage is individualized (e.g., 25-400 mg/day for adults, lower for children); follow titration schedule to avoid rash. If switching from other anticonvulsants, your doctor will adjust accordingly.

• Do not stop suddenly—taper gradually over 1-2 weeks under medical supervision.

Side Effects

• Headache

• Dizziness or ataxia (impaired coordination)

• Nausea or vomiting

• Drowsiness or insomnia

• Dry mouth

• Tremor or shaking

• Blurred or double vision

• Fatigue or weakness

• Back pain or abdominal pain

• Nasal congestion or upper respiratory infection

• Skin rash (mild to severe—monitor closely)

• Rare but serious: Suicidal ideation, severe rash (e.g., SJS/TEN), blood disorders (e.g., aplastic anemia), or multi-organ hypersensitivity

Safety Advice

• Avoid alcohol while taking Lamotrigine Dispersible Tablets IP 50 mg, as it can increase dizziness, drowsiness, and seizure risk.

• Use during pregnancy only if benefits outweigh risks (FDA pregnancy category C; no major teratogenic effects in human studies, but may require dose increase due to clearance changes—use effective contraception if applicable). Not recommended during breastfeeding, as it passes into milk (monitor infant for rash or apnea). Inform your doctor if pregnancy occurs or if a child starts menstruation (hormonal changes affect levels).

• Caution in liver impairment (reduced clearance; start low and monitor levels) or kidney disease (dose adjustment needed). Elderly patients may need lower doses due to slower metabolism.

• Monitor for mood changes or suicidal thoughts (especially in first months); report rash immediately, even if mild. Avoid driving or operating machinery until effects are known.

• Inform your doctor of all medications (e.g., valproate doubles lamotrigine levels; carbamazepine halves them) to prevent interactions or rash.

Storage Conditions

• Store at temperatures below 30°C (86°F).

FAQs

What is the use of Lamotrigine Dispersible Tablets IP 50mg?

Lamotrigine Dispersible Tablets IP 50mg is used in the treatment of Epilepsy (fits) and Bipolar disorder. It contains Lamotrigine, which reduces the electrical impulses and subsequent firing of the nerve impulses that cause fits. Lamotrigine Dispersible Tablets IP 50mg decreases the brain's excessive and abnormal nerve activity, thereby helping control seizures.

Can I stop taking Lamotrigine Dispersible Tablets IP 50mg if I feel well?

Do not discontinue Lamotrigine Dispersible Tablets IP 50mg without consulting your doctor. To treat your condition effectively, continue taking Lamotrigine Dispersible Tablets IP 50mg for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Lamotrigine Dispersible Tablets IP 50mg. Your doctor will reduce the dose gradually to avoid worsening seizures.

Does prolonged intake of Lamotrigine Dispersible Tablets IP 50mg cause weight gain?

Lamotrigine Dispersible Tablets IP 50mg may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

How can I cope with dry mouth?

Dry mouth could be a side-effect of Lamotrigine Dispersible Tablets IP 50mg. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Do Lamotrigine Dispersible Tablets IP 50mg treat bipolar disorder?

Lamotrigine Dispersible Tablets IP 50mg help to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

How does Lamotrigine Dispersible Tablets IP 50mg work?

Lamotrigine Dispersible Tablets IP 50mg decrease the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizure episodes.

What are the side effects of Lamotrigine Dispersible Tablets IP 50mg?

The side effects of Lamotrigine Dispersible Tablets IP 50mg include sleepiness, dizziness, tremor, back pain, headache, nausea, vomiting, diarrhoea, blurred or double vision, tiredness, fever, dry mouth, sore throat, stuffy nose, stomach pain and infections, including seasonal flu. However, if these side effects persist or worsen, please consult your doctor.

What is epilepsy?

Epilepsy, also called seizure disorder, is a brain-related disorder affecting people of all ages, characterised by repeated seizures that are brief episodes of involuntary movement that may involve a part of the body or the full body. It is caused due to abnormal electrical activity in the brain and sometimes followed by loss of consciousness and control of bladder or bowel function.

What is bipolar disorder?

Bipolar disorder, also called manic depression, is a mental illness that causes unusual shifts in a person's mood, energy, concentration, and activity levels. It is marked by episodes of mood swings ranging from depressive lows to manic highs.

How long does it take Lamotrigine Dispersible Tablets IP 50mg to work?

Though it is different from person to person, it may take about 6-8 weeks for your symptoms to improve.

What can be the consequences of taking a higher than the recommended dose of Lamotrigine Dispersible Tablets IP 50mg?

You may experience uncontrollable and quick eye movements, lack of coordination and clumsiness. High doses of Lamotrigine Dispersible Tablets IP 50mg may cause changes in heartbeat rhythm, balance problems, loss of consciousness, fits (convulsions) or coma. If you suspect you have taken more than the recommended dose of Lamotrigine Dispersible Tablets IP 50mg, seek medical help immediately, even if there are no signs of discomfort.

Can Lamotrigine Dispersible Tablets IP 50mg affect pregnancy?

Lamotrigine Dispersible Tablets IP 50mg shows no effect on pregnant women or their fetuses as per human population studies. However, if you become pregnant or are planning planning while taking Lamotrigine Dispersible Tablets IP 50mg, it is advisable to inform your doctor immediately. If Lamotrigine Dispersible Tablets IP 50mg is considered during pregnancy, your doctor may prescribe the lowest effective dose.

Can I take Lamotrigine Dispersible Tablets IP 50mg with other antiepileptic medicines?

You are recommended to consult your doctor before taking Lamotrigine Dispersible Tablets IP 50mg with other antiepileptic medicines to avoid drug interactions.

How to take Lamotrigine Dispersible Tablets IP 50mg?

Take Lamotrigine Dispersible Tablets IP 50mg as advised by the doctor. It can be taken with or without food. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

I have symptoms of depression. Can I take Lamotrigine Dispersible Tablets IP 50mg?

Yes, you can take Lamotrigine Dispersible Tablets IP 50mg if you have symptoms of depression. In fact, Lamotrigine Dispersible Tablets IP 50mg is used to prevent depression. However, do not self-medicate. Use Lamotrigine Dispersible Tablets IP 50mg only if prescribed by a doctor.