Product Description

Metformin SR IP 500 mg, Glimepiride 1 mg & Voglibose 0.2 mg Tablets IP is a fixed-dose triple-combination antidiabetic medication indicated for the management of type 2 diabetes mellitus. Type 2 diabetes is a metabolic disorder characterized by persistently elevated blood glucose levels due to insulin resistance, impaired insulin secretion, or both.

This formulation combines three complementary antidiabetic agents: Metformin (a biguanide), Glimepiride (a sulfonylurea), and Voglibose (an alpha-glucosidase inhibitor). Together, they provide effective control of both fasting and postprandial blood glucose levels when diet, exercise, or dual therapy alone is insufficient. The sustained-release (SR) formulation of Metformin enhances tolerability and ensures prolonged glucose-lowering action.

Uses

• Treatment of type 2 diabetes mellitus in adults
  

• Used when blood sugar levels are not adequately controlled with single or dual antidiabetic therapy
  

• Adjunct to diet and lifestyle modifications for improved glycemic control
  

How it Works

Metformin SR IP 500 mg, Glimepiride 1 mg & Voglibose 0.2 mg Tablets IP exert their effects through three distinct mechanisms:

• Metformin SR (500 mg): Reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues. The sustained-release formulation allows gradual drug release, minimizing gastrointestinal side effects.

• Glimepiride (1 mg): Stimulates pancreatic beta cells to enhance insulin secretion, thereby lowering blood glucose levels.

• Voglibose (0.2 mg): Delays carbohydrate digestion and absorption in the intestine by inhibiting alpha-glucosidase enzymes, reducing postprandial blood glucose excursions.

Together, these mechanisms provide comprehensive and sustained glycemic control.

Benefits

• Helps control both fasting and postprandial blood glucose levels

• Improves overall glycemic control in patients with type 2 diabetes

• Sustained-release Metformin enhances gastrointestinal tolerability

• Reduces the risk of long-term diabetes-related complications when used consistently

• Suitable for patients inadequately controlled on dual therapy

How to Use

Take the tablet exactly as prescribed by your healthcare provider.

• Swallow the tablet whole with water; do not crush, chew, or break it.

• Take it preferably with a meal to minimize gastrointestinal discomfort.

• Your healthcare provider may adjust the dose based on blood glucose levels and response.

• Do not discontinue the medication without consulting your healthcare provider.

Side Effects

Common side effects may include:

• Nausea
  

• Vomiting
  

• Diarrhoea
  

• Stomach pain or bloating
  

• Flatulence
  

• Dizziness
  

• Headache
  

• Risk of hypoglycemia (especially due to Glimepiride), with symptoms such as sweating, shakiness, or confusion
  

Consult your doctor if side effects are severe, persistent, or worsening.

Safety Advice

• Alcohol: Avoid alcohol consumption, as it may increase the risk of hypoglycemia and lactic acidosis.

• Pregnancy & Breastfeeding: Consult your healthcare provider before use; not recommended unless clearly advised.

• Kidney & Liver Disease: Use with caution; dose adjustment or avoidance may be required in cases of renal or hepatic impairment.

• Hypoglycemia Risk: Monitor blood glucose levels regularly, especially in elderly patients or those with comorbidities.

• Contraindications: Not recommended in type 1 diabetes, diabetic ketoacidosis, or severe renal/hepatic impairment.

• Monitoring: Regular blood glucose, kidney function, and liver function tests are advised.

Storage Conditions

• Store below 30°C (86°F)
  

• Protect from light and moisture
  

• Keep out of reach of children
  

FAQs

What is Metformin SR IP 500 mg, Glimepiride 1 mg & Voglibose 0.2 mg Tablets IP used for?

It is used to manage type 2 diabetes mellitus when blood sugar levels are not adequately controlled with simpler treatments.

Can this medicine cause low blood sugar?

Yes, hypoglycemia may occur, especially if meals are skipped, alcohol is consumed, or physical activity is increased.

Can I stop this medicine once my blood sugar is controlled?

No. Diabetes requires long-term management. Do not stop the medicine without consulting your doctor.

Is this medicine safe for long-term use?

Yes, when taken as prescribed and monitored regularly by a doctor.

What should I do if I miss a dose?

Take it as soon as you remember. If it is close to the next dose, skip the missed dose. Do not take a double dose.