Product Description

Metformin Hydrochloride 500 mg (Sustained Release), Voglibose 0.3 mg & Glimepiride 2 mg Tablets IP is a fixed-dose triple-combination oral antidiabetic medication used for the management of type 2 diabetes mellitus. Type 2 diabetes is a chronic metabolic disorder characterised by persistently elevated blood glucose levels due to insulin resistance, impaired insulin secretion, or both.

This formulation combines Metformin (a biguanide), Glimepiride (a sulfonylurea), and Voglibose (an alpha-glucosidase inhibitor) to provide comprehensive control of fasting as well as post-prandial blood glucose levels. The sustained-release form of Metformin ensures prolonged action with improved gastrointestinal tolerability.

Uses

• Treatment of type 2 diabetes mellitus in adults
  

• Used when blood glucose levels are not adequately controlled with diet, exercise, or dual antidiabetic therapy
  

• Adjunct to lifestyle modification for improved glycaemic control
  
  

How it Works

Metformin Hydrochloride 500 mg (Sustained Release), Voglibose 0.3 mg & Glimepiride 2 mg Tablets IP work through three complementary mechanisms:

• Metformin SR (500 mg): Reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues. The sustained-release formulation allows gradual drug release and reduces gastrointestinal side effects.
  

• Glimepiride (2 mg): Stimulates pancreatic beta cells to release insulin, thereby lowering blood glucose levels.
  

• Voglibose (0.3 mg): Inhibits intestinal alpha-glucosidase enzymes, delaying carbohydrate digestion and absorption, which helps prevent sharp post-meal blood glucose spikes.
  

Together, these actions provide effective and sustained glycaemic control.

Benefits

• Helps control both fasting and post-meal blood glucose levels
  

• Provides enhanced glycaemic control in patients requiring intensified therapy
  

• Sustained-release Metformin improves tolerability and compliance
  

• Reduces the risk of long-term diabetes-related complications when used regularly
  

• Suitable for patients inadequately controlled on lower-dose combinations
  
  

How to Use

• Take the tablet exactly as prescribed by your doctor
  

• Swallow the tablet whole with water; do not crush, chew, or break it
  

• Take preferably with a meal to minimise gastrointestinal discomfort
  

• Dosage adjustments should be made only under medical supervision
  

• Do not stop the medication abruptly without consulting your doctor
  
  

Side Effects

Common side effects may include:

• Nausea
  

• Vomiting
  

• Diarrhoea
  

• Abdominal discomfort or bloating
  

• Flatulence
  

• Dizziness or headache
  

• Hypoglycaemia (especially due to Glimepiride), with symptoms such as sweating, tremors, weakness, or confusion
  

Consult your doctor if side effects are severe, persistent, or worsening.

Safety Advice

• Alcohol: Avoid alcohol, as it may increase the risk of hypoglycaemia and lactic acidosis
  

• Pregnancy & Breastfeeding: Consult your doctor before use; not recommended unless clearly advised
  

• Kidney & Liver Disease: Use with caution; dose adjustment or avoidance may be required in severe impairment
  

• Hypoglycaemia Risk: Regular blood glucose monitoring is essential, especially in elderly patients
  

• Contraindications: Not recommended in type 1 diabetes, diabetic ketoacidosis, or severe renal/hepatic impairment
  

• Monitoring: Periodic monitoring of blood glucose, kidney function, and liver function is advised
  
  

Storage Conditions

• Store below 30°C (86°F)
  

• Protect from light and moisture
  

• Keep out of reach of children
  
  

FAQs

What are Metformin SR 500 mg, Voglibose 0.3 mg & Glimepiride 2 mg Tablets IP used for?

It is used to manage type 2 diabetes mellitus when blood sugar levels are not adequately controlled with simpler treatments.

Can this medicine cause low blood sugar?

Yes. Hypoglycaemia may occur, particularly if meals are skipped, alcohol is consumed, or physical activity is increased.

Can I stop taking this medicine once my blood sugar is controlled?

No. Diabetes requires long-term management. Do not stop the medicine without consulting your doctor.

Is this medicine safe for long-term use?

Yes, when taken as prescribed and monitored regularly by a doctor.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is close to the next dose, skip the missed one. Do not take a double dose.