Product Description

Metformin 500mg (Sustained Release), Glimepiride 2mg, and Pioglitazone 15mg Tablets IP are a combination anti-diabetic medication for adults with type 2 diabetes. It is typically prescribed when blood sugar levels are not adequately controlled by diet and exercise alone, or by monotherapy with glimepiride or metformin.

Uses

Treatment of Type 2 diabetes mellitus

How it works

This tablet is a combination of three antidiabetic medicines: Glimepiride, Metformin, and Pioglitazone.

• Glimepiride (a sulfonylurea) stimulates insulin release from the pancreas to lower blood glucose.

• Metformin (a biguanide) reduces hepatic glucose production, delays intestinal glucose absorption, and improves insulin sensitivity.

• Pioglitazone (a thiazolidinedione) enhances insulin sensitivity in peripheral tissues.

• Together, they provide comprehensive blood sugar control when single or dual therapies are insufficient.

Benefits

• Helps control high blood glucose levels in type 2 diabetes.

• Improves insulin sensitivity and reduces glucose production, aiding in better post-meal blood sugar management.

• Used alongside diet and exercise for optimal glycemic control. Continue as prescribed by your doctor.

How to use

• Swallow the tablet whole with a glass of water, with or without food; do not break, chew, or crush it.

• Take at the same time each day as directed by your doctor. Do not skip doses.

Side Effects

Common side effects may include:

• Hypoglycemia (low blood glucose level)

• Headache

• Nausea

• Diarrhoea

• Dizziness

• Vomiting

• Anemia (low number of red blood cells)

• Weakness

• Sinus infection

Report any persistent or severe symptoms to your doctor.

Safety Advice

• Alcohol: Avoid alcohol, as it may increase hypoglycemia risk and lactic acidosis.

• Pregnancy and Breastfeeding: May be unsafe during pregnancy due to potential fetal harm. Consult your doctor; use only if the benefits outweigh risks. Not recommended while breastfeeding.

• Kidney/Liver/Heart Conditions: Use with caution; inform your doctor of renal, hepatic, or cardiac issues, as dose adjustments or avoidance may be needed.

• Contraindications: Do not use if you have severe renal impairment, hepatic disease, heart failure, bladder cancer history, or hypersensitivity to the ingredients. Not for type 1 diabetes or diabetic ketoacidosis.

• Drug Interactions: Inform your doctor about medications like insulin, NSAIDs, diuretics, or CYP2C8 inducers/inhibitors, as they may affect efficacy or increase side effects.

• Monitoring: Regular blood glucose, liver function, weight, and edema checks are advised. Monitor for signs of hypoglycemia or heart issues.

• Consult your doctor if you are elderly or have other conditions.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

Can I drink alcohol while taking Metformin 500mg, Glimepiride 2mg & Pioglitazone 15mg Tablet?

No, it is not safe to drink alcohol while using Metformin 500mg, Glimepiride 2mg & Pioglitazone 15mg Tablet. Drinking alcohol may lower your blood sugar levels (hypoglycemia). It may also elevate the risk of developing lactic acidosis.

What should I inform the doctor before taking Metformin 500mg, Glimepiride 2mg & Pioglitazone 15mg Tablet?

Before taking Metformin 500mg, Glimepiride 2mg & Pioglitazone 15mg Tablet, inform your doctor if you have congestive heart failure, kidney problems, liver problems, or swelling of the back of the eye. Inform the doctor if you are pregnant, breastfeeding, or a premenopausal woman. Inform your doctor about all prescription and non-prescription medications, vitamins, and herbal supplements you are taking.

Can the use of Metformin 500mg, Glimepiride 2mg & Pioglitazone 15mg Tablet lead to Vitamin B12 deficiency?

Yes, the use of Metformin 500mg, Glimepiride 2mg & Pioglitazone 15mg Tablet can cause vitamin B12 deficiency as it contains metformin in it. Prolonged use may disrupt the absorption of vitamin B12 in the stomach.

Can the use of Metformin 500mg, Glimepiride 2mg & Pioglitazone 15mg Tablet cause hypoglycemia?

Yes, the use of Metformin 500mg, Glimepiride 2mg & Pioglitazone 15mg Tablet can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, rapid heartbeat, and feelings of anxiety or shakiness. or shaky. It happens more often if you miss or delay your meal, drink alcohol, over-exercise, or take other antidiabetic medicines along with it. Regular monitoring of blood glucose levels is essential. Always carry some sugary items like candy or chocolate with you.