Product Description

Naproxen 250 mg and Domperidone 10 mg Tablet IP is a combination medication primarily used to treat migraine headaches and to relieve pain associated with conditions such as rheumatoid arthritis, gout, and dysmenorrhea (menstrual pain). Migraine is a neurological condition characterized by severe, often debilitating headaches, while pain can arise from various inflammatory or musculoskeletal disorders.

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclo-oxygenase (COX) enzymes (both COX-1 and COX-2), leading to reduced synthesis of prostaglandins—chemicals responsible for pain, inflammation, and fever. Domperidone is an antiemetic and prokinetic agent that prevents nausea and vomiting by blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) of the brain, without significant penetration of the blood-brain barrier, thus minimizing central nervous system side effects.

Uses

• Management of migraine headaches

• Relief of pain associated with rheumatoid arthritis, gout, and dysmenorrhea (menstrual pain)

How it works

Naproxen 250 mg & Domperidone 10 mg Tablet IP combines two active ingredients:

• Naproxen inhibits cyclo-oxygenase (COX) enzymes, reducing prostaglandin production, which decreases pain and inflammation.

• Domperidone blocks dopamine receptors in the chemoreceptor trigger zone (CTZ), preventing nausea and vomiting and promoting gastric motility to aid digestion.

Benefits

This combination provides effective pain relief and anti-inflammatory action from naproxen, while domperidone helps prevent nausea and vomiting often associated with migraine or NSAID use. Domperidone also enhances gastric emptying, which can improve drug absorption and reduce gastrointestinal discomfort.

How to use

Take the tablet whole with water; do not crush, break, or chew it. Follow the dosage and duration prescribed by your healthcare provider.

Side Effects

• Abdominal pain

• Constipation

• Indigestion

• Flatulence

• Dry mouth

• Glossitis (inflammation of the tongue)

• Diarrhea

• Drowsiness

• Dizziness

• Headache

• Vision problems (rare)

• Hearing problems (rare)

Safety Advice

• Avoid alcohol while taking Naproxen and Domperidone, as it may increase the risk of dizziness, drowsiness, and gastrointestinal irritation.

• Use Naproxen 250 mg and Domperidone 10 mg Tablet IP during pregnancy only if clearly needed and prescribed by a doctor, as naproxen may affect fetal development, especially in the third trimester.

• Inform your doctor if you have a history of heart disease, gastrointestinal ulcers, liver, or kidney problems before using this medication.

• Prolonged or frequent use of naproxen may increase the risk of cardiovascular events and cause liver or kidney damage; use only as directed.

Storage Conditions

• Store at a temperature below 86°F (30 °C).

FAQs

What is the use of Naproxen 250 mg & Domperidone 10 mg Tablet IP?

It is used to treat migraine headaches and relieve pain associated with rheumatoid arthritis, gout, and dysmenorrhea.

How does Naproxen 250 mg & Domperidone 10 mg Tablet IP work?

Naproxen reduces pain and inflammation by inhibiting COX enzymes and prostaglandin production. Domperidone prevents nausea and vomiting by blocking dopamine receptors in the brain’s vomiting center and promotes gastric motility.

Can Naproxen 250 mg & Domperidone 10 mg Tablet IP permanently cure migraine?

No, it does not cure migraine, but it helps relieve the pain and associated symptoms.

Can Naproxen 250 mg & Domperidone 10 mg Tablet IP be taken long-term?

Long-term or frequent use may cause liver, kidney, or cardiovascular problems. Use only as prescribed by your doctor.