Product Description

Pioglitazone 15mg & Metformin 500mg Sustained Release Tablet is an anti-diabetic medication used to treat Type 2 diabetes mellitus. Type 2 diabetes, also known as non-insulin-dependent diabetes mellitus (NIDDM) or maturity-onset diabetes, occurs when the body either does not produce enough insulin, the insulin produced does not function effectively, or there is excess production of glucagon. Insulin is a hormone that helps reduce blood sugar levels, especially after eating.

This tablet contains two antidiabetic agents: Pioglitazone (a thiazolidinedione) and Metformin (a biguanide). Pioglitazone lowers blood sugar by activating peroxisome proliferator-activated receptor gamma (PPAR-γ) in cells, which enhances insulin sensitivity and increases glucose uptake. Metformin reduces glucose production in the liver and increases glucose utilization by the body’s cells, thereby lowering elevated blood sugar levels. This combination is prescribed for adults with Type 2 diabetes when Metformin alone does not provide adequate glycemic control.

Pioglitazone 15mg & Metformin 500mg Sustained Release Tablet should be taken with food to minimize gastrointestinal side effects.

Uses

Treatment of Type 2 diabetes mellitus (non-insulin-dependent diabetes)

How it works

Pioglitazone 15mg & Metformin 500mg Sustained Release Tablet combines two antidiabetic agents:

• Pioglitazone activates PPAR-γ receptors, increasing insulin sensitivity and promoting glucose uptake from the bloodstream into cells.

• Metformin decreases hepatic glucose production and enhances peripheral glucose uptake and utilization.

Together, they help control high blood sugar levels in adults with Type 2 diabetes, especially when Metformin alone is insufficient.

Benefits

• Effectively lowers blood glucose levels in patients with Type 2 diabetes.

• Improves insulin sensitivity and glucose utilization.

• Helps reduce the risk of diabetes-related complications affecting the heart, kidneys, eyes (retinopathy), nerves (neuropathy), and blood vessels in the feet (diabetic foot ulcers).

• Sustained release formulation provides prolonged blood sugar control with reduced gastrointestinal side effects.

How to use

Swallow Pioglitazone 15mg & Metformin 500mg Sustained Release Tablet whole with water. Do not crush, break, or chew the tablet. Take it with food to reduce stomach upset.

Side Effects

• Diarrhea

• Loss of appetite

• Headache

• Nausea

• Vomiting

Safety Advice

• Avoid alcohol while taking this medicine, as it may cause dangerous fluctuations in blood sugar levels.

• Not recommended during pregnancy. If you are pregnant, planning to conceive, or think you might be pregnant, consult your doctor immediately.

• Pioglitazone may cause fluid retention, increasing the risk of heart failure, especially in patients taking insulin or with pre-existing heart conditions. Your doctor will monitor you closely.

• Rarely, Pioglitazone may cause liver damage; liver function tests are recommended during treatment.

• Use with caution in patients with high blood pressure.

• This medicine is generally safe for driving if blood sugar levels are stable, but avoid combining it with other blood sugar-lowering drugs without medical advice.

Storage Conditions

• Store at a temperature below 86°F (30 °C).

FAQs

What is the use of Pioglitazone 15mg & Metformin 500mg Tablet?

It is used to treat Type 2 diabetes by lowering blood sugar through improved insulin sensitivity and reduced glucose production.

Can Pioglitazone 15mg & Metformin 500mg Tablet cause heart failure?

Pioglitazone can cause fluid retention, which may increase the risk of heart failure. Doctors usually start with a low dose and monitor patients closely.

Can Pioglitazone 15mg & Metformin 500mg Tablet cause liver damage?

Rarely, it may cause liver damage. Regular liver function monitoring is advised during treatment.

Can Pioglitazone 15 mg & Metformin 500 mg Tablet be taken by patients with high blood pressure?

Pioglitazone 15 mg & Metformin 500 mg Tablet should be used with caution in patients with high Blood pressure.

Can Pioglitazone 15 mg & Metformin 500 mg Tablet affect my ability to drive?

This medicine is generally safe for driving or operating machinery if your blood sugar levels are stable. However, take precautions and avoid combining it with other blood sugar-lowering medications without medical guidance.

Can Pioglitazone 15 mg & Metformin 500 mg Tablet be taken with contraceptives?

It is usually safe to take Pioglitazone & Metformin alongside contraceptives, but always consult your doctor to ensure there are no interactions specific to your health condition.

What is Type 2 diabetes mellitus?

A condition where the body does not produce enough insulin or cannot use it effectively, leading to high blood sugar levels. Symptoms include increased thirst, frequent urination, hunger, fatigue, and blurred vision.