Product Description

Pregabalin 75 mg & Nortriptyline 10 mg Tablets are a combination medicine used to manage neuropathic pain associated with conditions such as diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury. Neuropathic pain is a chronic condition resulting from nerve damage or dysfunction in the nervous system, leading to persistent and often debilitating nerve pain.

This combination contains two active ingredients: Pregabalin 75 mg, an anticonvulsant and neuropathic pain agent, and Nortriptyline 10 mg, a tricyclic antidepressant (TCA). Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters and thereby decreasing pain signal transmission. Nortriptyline inhibits the reuptake of serotonin and noradrenaline, increasing their levels in the brain and modulating pain pathways to reduce the intensity of pain signals. Together, these medicines provide effective relief from neuropathic pain.

Uses

Pregabalin 75 mg & Nortriptyline 10 mg Tablets are used to treat neuropathic pain caused by conditions such as diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury.

How it works

This combination works by targeting different mechanisms involved in pain transmission:

• Pregabalin reduces the release of neurotransmitters involved in pain signaling by binding to calcium channels in nerve cells.

• Nortriptyline, a tricyclic antidepressant, increases the levels of serotonin and noradrenaline in the brain by inhibiting their reuptake, which helps modulate and reduce pain perception.

Together, they provide a synergistic effect to alleviate neuropathic pain.

Benefits

• Effective management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury.

• Combines two complementary mechanisms to improve pain relief when monotherapy is insufficient.

• Helps improve the quality of life by reducing chronic nerve pain symptoms.

How to use

• Take Pregabalin 75 mg & Nortriptyline 10 mg Tablets exactly as prescribed by your doctor.
• These tablets can be taken with or without food.
• Swallow the tablets whole with a glass of water; do not chew, crush, or break them.

Side Effects

Common side effects may include:

• Dizziness

• Sleepiness or drowsiness

• Nausea

• Blurred vision

• Peripheral oedema (swelling of the lower legs and hands)

• Weight gain

• Dry mouth

If you experience any severe or persistent side effects, consult your doctor promptly.

Safety Advice

• Avoid alcohol consumption while taking these tablets, as it may increase drowsiness and sedation.

• Use caution if you have a history of heart problems, as nortriptyline may cause QT interval prolongation.

• Do not stop taking the medication without consulting your healthcare provider.

• Inform your doctor about any other medications you are taking to avoid potential interactions.

Storage Conditions

Store at a temperature below 75°F (25°C). Protect from light and moisture.

FAQs

What is the use of Pregabalin 75mg & Nortriptyline 10mg Tablets?

They are used to treat neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, and similar conditions.

How do Pregabalin 75mg and Nortriptyline 10mg Tablets work?

Pregabalin reduces neurotransmitter release involved in pain signaling, while nortriptyline increases serotonin and noradrenaline levels in the brain, together reducing pain perception.

How to cope with dry mouth?

Reduce caffeine intake, avoid smoking and alcohol-based mouthwashes, stay hydrated, and chew sugar-free gum or candy to stimulate saliva production.

Can I stop Pregabalin 75mg and Nortriptyline 10mg Tablets use if I feel well?

No. Continue the medication for the full duration prescribed by your doctor. Consult your healthcare provider before making any changes.

Are Pregabalin 75mg & Nortriptyline 10mg Tablets used to treat diabetic neuropathy?

Yes, they are effective in managing nerve pain caused by diabetic neuropathy, which results from nerve damage due to high blood sugar levels.

Do pregabalin and nortriptyline tablets cause oedema?

Peripheral oedema (swelling of hands and lower legs) can occur. Avoid prolonged sitting or standing, and elevate your legs when resting.

Do Pregabalin 75mg and Nortriptyline 10mg Tablets cause weight gain?

Weight gain may occur, mainly due to increased appetite. Maintain a balanced diet and regular exercise to manage your weight.