Product Description

Pregabalin Capsules IP 75 mg is an anticonvulsant and neuropathic pain medication used to treat nerve pain associated with conditions like diabetic neuropathy, postherpetic neuralgia (nerve pain after shingles), and spinal cord injury.

It is also indicated for fibromyalgia and as an adjunctive therapy for partial-onset seizures in adults. Pregabalin works by modulating nerve signals in the central nervous system, providing relief from chronic pain and seizure activity. This medication is available by prescription and should be used under medical supervision, as it carries risks of dependence and side effects.

Uses

1.) Treatment of neuropathic pain, including:

• Diabetic neuropathy (nerve damage due to diabetes).

• Postherpetic neuralgia (pain following shingles).

• Neuropathic pain from spinal cord injury.

2.) Management of fibromyalgia (a condition causing widespread musculoskeletal pain).

3.) Adjunctive therapy for partial-onset seizures in adults with epilepsy.

It is not indicated for other types of seizures or as a first-line treatment for anxiety, though it may be used off-label in some cases.

How it works

Pregabalin Capsules IP 75 mg contain pregabalin, which binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of excitatory neurotransmitters like glutamate, norepinephrine, and substance P, thereby decreasing abnormal nerve signaling. 

As a result, it alleviates neuropathic pain, reduces seizure frequency, and improves fibromyalgia symptoms. The onset of action is typically 1 hour for pain relief, with peak effects in 2–4 hours, and it is eliminated unchanged via the kidneys with a half-life of about 6 hours. 

Benefits

• Effective pain management: Reduces neuropathic pain intensity by 30–50% in clinical trials (e.g., from the Journal of Pain), improving sleep, mood, and daily function in conditions like diabetic neuropathy.

• Seizure control: As an adjunct, it lowers partial seizure frequency by 20–40%, based on studies in Epilepsy Research.

• Versatile therapy: Helps with fibromyalgia by addressing central sensitization, offering a better quality of life without the addictive potential of some other pain medications.

How to use

This information is a general guide for taking Pregabalin Capsules IP 75 mg. For your specific health condition and dosage, you must follow your doctor's instructions.
Take the capsules orally with a glass of water/with or without food, and swallow the whole tablet do not chew, crush, or break the capsules.

To maintain a consistent level of medication in your body, take your doses at approximately the same time each day.

Side Effects

Common side effects (usually dose-related and may subside with continued use):

• Neurological: Dizziness, sleepiness, headache, difficulty concentrating.

• Other: Weight gain, blurred or double vision, swelling (fluid retention or peripheral edema), nausea, constipation, or diarrhea.

• Mood-related: Mood swings or euphoria (rare).

Seek medical attention if side effects persist, worsen, or include severe reactions like suicidal thoughts or allergic rash.

Safety Advice

• Alcohol Interaction: Avoid alcohol, as it can increase dizziness and sedation risks.

• Pregnancy and Breastfeeding: Classified as Pregnancy Category C (animal studies show risks, and human data are limited), so use only if benefits outweigh risks. It may cause fetal harm; consult your doctor if pregnant or breastfeeding, as it's excreted in breast milk.

• Other Precautions: Use with caution in patients with kidney impairment (dose reduction needed), history of substance abuse (due to dependence risk), or mental health issues (monitor for suicidal ideation). Not recommended for children under 1 month. Inform your doctor of all medications to avoid interactions (e.g., with opioids or sedatives). Gradual tapering is essential to prevent withdrawal symptoms like anxiety or seizures. Regular blood tests and monitoring for weight gain or edema are advised.

• Lifestyle Advice: Avoid driving or operating machinery if drowsy; monitor blood sugar if diabetic; maintain a balanced diet to manage weight gain.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

Can children take Pregabalin?

Yes, but typically only for seizures. The safety and efficacy for other conditions, such as nerve pain and fibromyalgia, have not been established in children under 18 years of age.

Is Pregabalin addictive?

Yes, Pregabalin is a controlled substance with a risk of misuse and dependence. The risk is higher for those with a history of substance abuse. Long-term use can lead to physical dependence, and stopping abruptly can cause withdrawal symptoms.

Can alcohol be consumed while taking Pregabalin? 

Alcohol consumption is not recommended. Combining alcohol with Pregabalin may increase the risk of dizziness and drowsiness.

What should be done if a dose is missed?

Take the missed dose as soon as remembered, unless it is almost time for the next dose. If so, skip the missed dose and continue the regular schedule. A double dose should not be taken to make up for a missed one.

What should be done before and during surgery?

Inform doctors and dentists about taking Pregabalin before any surgical procedures. They need to be aware of all medications to avoid interactions.

Can one drive or operate machinery while taking Pregabalin?

Driving or operating heavy machinery should be avoided until aware of the medication's effects due to the risk of dizziness, drowsiness, and blurred vision.