Product Description

Sacubitril 49mg & Valsartan 51mg Tablets IP is used in the treatment of chronic heart failure with reduced ejection fraction (HFrEF) in adults (NYHA class II-IV), reducing the risk of cardiovascular death and hospitalization.

It may also be used in children aged 1-18 years for symptomatic heart failure with systemic left ventricle. Heart failure is a condition where the heart cannot pump blood effectively, leading to symptoms like shortness of breath and fatigue.

Uses

Treatment of chronic heart failure with reduced ejection fraction.

How it works

Sacubitril 49mg & Valsartan 51mg Tablets IP combines Valsartan (an angiotensin II receptor blocker, ARB) and Sacubitril (a neprilysin inhibitor). Valsartan blocks angiotensin II receptors, relaxing and widening blood vessels to ease heart pumping. Sacubitril inhibits neprilysin, preventing the breakdown of natriuretic peptides (like BNP), which promote vasodilation, natriuresis (sodium excretion), and reduce cardiac stress. Together, they improve heart function and reduce blood pressure.

Benefits

This medication helps manage heart failure symptoms, reduces the risk of hospitalization, and may lower mortality in patients with HFrEF. It improves quality of life by alleviating fatigue and shortness of breath. Benefits are supported by clinical trials and depend on adherence to treatment.

How to use

Swallow sacubitril-valsartan tablets whole with water; do not crush, break, or chew them.

Side Effects

• Common: Cough, dizziness, diarrhea, fainting, headache, nausea, stomach pain, vertigo, weakness.

• Rare but serious: Angioedema (swelling of face/throat), hyperkalemia (high potassium), severe hypotension, and kidney impairment. Seek immediate medical help for severe symptoms.

Safety Advice

• Avoid alcohol consumption while taking Sacubitril 49mg & Valsartan 51mg Tablets IP, as it may worsen side effects like dizziness or low blood pressure.

• Not recommended during pregnancy (Category D; may harm the fetus). Consult your doctor if planning a pregnancy.

• Contraindicated if you have hypersensitivity to ARBs/ACEIs, severe kidney/liver disease, or bilateral renal artery stenosis.

• Inform your doctor about medications (e.g., potassium supplements, NSAIDs) to avoid interactions.

• Monitor blood pressure, potassium levels, and kidney function regularly. Not recommended while breastfeeding.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

Can I stop taking Sacubitril 49mg & Valsartan 51mg Tablets IP if I feel better?

Please do not stop taking Sacubitril 49mg & Valsartan 51mg Tablets IP without consulting your doctor on your own, as it may lead to a rise in blood pressure. Continue taking Sacubitril 49mg & Valsartan 51mg Tablets IP for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Sacubitril 49mg & Valsartan 51mg Tablets IP.

Do Sacubitril 49mg & Valsartan 51mg Tablets IP cause orthostatic hypotension?

Orthostatic hypotension could be a side-effect of Sacubitril 49mg & Valsartan 51mg Tablets IP. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Sacubitril 49mg & Valsartan 51mg Tablets IP are advised to monitor their blood pressure levels to avoid unpleasant events regularly.

What happens when the blood pressure is high?

High blood pressure increases the workload on the arteries and heart. If untreated, it could damage the heart, brain, and kidneys' blood vessels, resulting in a stroke, heart failure, or kidney failure. Hypertension increases the risk of heart attacks.

Can I take potassium supplements with Sacubitril 49mg & Valsartan 51mg Tablets IP?

Talk to your doctor before taking potassium supplements, potassium-sparing diuretics, or salt substitutes along with Sacubitril 49mg & Valsartan 51mg Tablets IP, as it might cause an increase in serum potassium and serum creatinine levels.

Do Sacubitril 49mg & Valsartan 51mg Tablets IP cause headache?

Sacubitril 49mg & Valsartan 51mg Tablets IP may cause a headache as a common side effect, especially in the first few days of treatment. However, if the condition persists or worsens, please consult a doctor to reduce the dose initially.

Are Sacubitril 49mg & Valsartan 51mg Tablets IP safe for patients with hypotension?

Sacubitril 49mg & Valsartan 51mg Tablets IP is not recommended for patients with severe hypotension (low blood pressure) as it may increase the risk of worsening the condition. Therefore, inform your doctor if you have low blood pressure before taking Sacubitril 49mg & Valsartan 51mg Tablets IP.