Product Description

Sitagliptin 100 mg, Dapagliflozin 10 mg & Metformin 1000 mg SR Tablets IP is a fixed-dose triple combination oral antidiabetic medication for adults with type 2 diabetes mellitus (T2DM). It integrates sitagliptin (a DPP-4 inhibitor), dapagliflozin (an SGLT2 inhibitor), and metformin sustained-release (SR, a biguanide) to provide multifaceted glycemic control. This therapy is indicated when dual combinations (e.g., sitagliptin + metformin or dapagliflozin + metformin) or metformin monotherapy fail to achieve targets. T2DM arises from insulin resistance, beta-cell dysfunction, and excess hepatic glucose production; this combination addresses these via complementary mechanisms, improving HbA1c by 1.5–2% over monotherapy in trials (e.g., similar to Qternmet XR data). It is prescription-only and must be used with diet and exercise.

Uses

• Improvement of glycemic control in adults with T2DM inadequately managed by dual therapy or metformin alone, as an adjunct to diet/exercise

• Management of hyperglycemia in patients with comorbidities (e.g., obesity, hypertension, or CV risk), leveraging dapagliflozin's cardiorenal benefits

• Not indicated for type 1 diabetes, diabetic ketoacidosis (DKA), gestational diabetes, or patients with severe renal impairment

How it works

This triple therapy targets multiple glucose-regulating pathways for synergistic effects:

• Sitagliptin (100 mg): A DPP-4 inhibitor that prolongs incretin hormones (GLP-1 and GIP) by preventing their enzymatic degradation. This enhances glucose-dependent insulin secretion from pancreatic beta cells and suppresses glucagon release from alpha cells, reducing postprandial hyperglycemia without hypoglycemia risk.

• Dapagliflozin (10 mg): An SGLT2 inhibitor that blocks sodium-glucose cotransporter 2 in the proximal renal tubules, increasing urinary glucose excretion (glucosuria, ~50–70 g/day). This lowers blood glucose independently of insulin, promotes modest weight loss (2–3 kg via caloric loss), and reduces blood pressure (via natriuresis and osmotic diuresis).

• Metformin SR (1000 mg): Decreases hepatic gluconeogenesis and glycogenolysis, improves peripheral insulin sensitivity, and enhances glucose uptake in muscles. The SR formulation provides gradual release over 24 hours, minimizing GI side effects compared to immediate-release.

Combined, they reduce fasting/postprandial glucose and HbA1c, with full effects in 4–12 weeks.

Benefits

The tablets containing Sitagliptin 100mg, Dapagliflozin 10mg, and Metformin 1000mg ER offer a range of benefits for adults with type 2 diabetes. The combination of three different drug classes provides a powerful and comprehensive approach to controlling blood sugar. This medication can significantly lower/reduce glycated hemoglobin (HbA1c), an important indicator of average blood sugar levels over time. Dapagliflozin can lead to weight loss by causing the body to excrete excess glucose, and it has been shown to reduce the risk of heart failure and improve cardiovascular health in diabetic patients.

How to use

When using Sitagliptin 100mg, Dapagliflozin 10mg, and Metformin 1000mg ER tablets, it is essential to follow your doctor's instructions. Here is a general guide on how to use this medication: Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, and it can be taken with a meal, preferably the evening meal, to minimize gastrointestinal side effects. If you forget a dose, take it as soon as you remember. Regularly check your blood sugar levels as directed by your doctor. Excessive alcohol consumption can increase the risk of lactic acidosis.

Side Effects

Common side effects (often mild and transient):

• Gastrointestinal (from metformin): diarrhea, nausea, vomiting, abdominal pain, flatulence

• General: headache, fatigue

• From dapagliflozin: urinary tract infections (UTIs), genital mycotic infections (e.g., yeast), increased urination, thirst

Less common/rare but serious side effects (seek immediate medical attention):

• Hypoglycemia: Rare alone but possible with insulin/sulfonylureas (symptoms: shakiness, sweating, confusion)

• Lactic acidosis (metformin-related): Muscle pain, weakness, breathing difficulty, hypothermia—higher risk in renal/hepatic impairment or alcohol use

• Ketoacidosis/euglycemic DKA (dapagliflozin-related): Nausea, abdominal pain, fatigue (even with normal glucose)

• Pancreatitis (sitagliptin-related): Severe abdominal pain radiating to back

• Other: Severe joint pain (arthralgia), dehydration/volume depletion, bone fractures (long-term SGLT2i), vitamin B12 deficiency (metformin)

• Report persistent symptoms; side effects decrease with time or dose adjustment.

Safety Advice

Safety advice for using Sitagliptin 100mg, Dapagliflozin 10mg, and Metformin 1000mg ER tablets: always take the tablet with a meal, preferably in the evening, to minimize gastrointestinal side effects. It is extended-release (ER) and must be swallowed whole. Do not crush, chew, or break it, as this can cause all the medication to be released at once. Regularly monitor your blood glucose levels as directed by your doctor.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

What are Sitagliptin, Dapagliflozin, and Metformin used for?

This combination medication manages type 2 diabetes in adults when diet, exercise, and other treatments are not enough to control blood sugar levels.

Does this medication cure type 2 diabetes?

No, it manages blood sugar levels but does not cure the condition.

How long does it take for this medication to work?

Initial improvements may be seen in a few days, with full benefits taking several weeks.

How should this medication be taken?

Typically, one tablet is taken daily with a meal, often in the evening, and swallowed whole.

What should be done if a dose is missed?

Take a missed dose when remembered, but skip it if the next dose is due soon. Do not double doses.

Can this medication be stopped if blood sugar levels are controlled?

Do not stop without consulting a doctor, as it could lead to high blood sugar.

Is it still necessary to monitor blood sugar while taking this medication?

Yes, regular monitoring is necessary to confirm the medication's effectiveness.

Can this medication cause low blood sugar (hypoglycemia)?

The risk is low, but possible, especially with concurrent use of insulin or other similar medications.

Are there any serious side effects to be aware of?

Serious but rare side effects include lactic acidosis, pancreatitis, diabetic ketoacidosis, and Fournier's gangrene. Seek immediate medical help if symptoms occur.

Who should not take this medication?

It's not for those with type 1 diabetes, severe kidney issues, or diabetic ketoacidosis.

What about pregnancy and breastfeeding?

This medication is not advised during pregnancy or breastfeeding; discuss alternatives with a doctor.