Product Description

Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets IP belong to the class of anti-diabetic agents used to treat Type 2 diabetes mellitus. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone that helps decrease blood sugar levels) or there is resistance to the action of insulin. As a result, the body produces large amounts of insulin, but it cannot effectively act on the organs.

Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets is a combination drug containing Sitagliptin and Metformin. Metformin reduces the release of stored sugar (glucose) from the liver, decreases sugar absorption from the gastrointestinal tract, and improves the body’s sensitivity to insulin, enhancing glucose utilization. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of incretin hormones, which stimulate the pancreas to release more insulin and reduce glucagon secretion, helping regulate blood sugar levels. Together, Sitagliptin Phosphate 50 mg & Metformin Hydrochloride 1000 mg Tablets help prevent blood glucose levels from rising excessively after meals.

Uses

Treatment of Type 2 Diabetes Mellitus

How it works

Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets combine the actions of Sitagliptin and Metformin. Metformin works by reducing hepatic glucose production, lowering intestinal glucose absorption, and improving peripheral glucose uptake and utilization. Sitagliptin enhances the body's incretin system, increasing insulin release and decreasing glucagon levels in a glucose-dependent manner. This combination helps maintain blood glucose levels within the normal range, especially after meals.

Benefits

Istamet 50 mg/1000 mg Tablet helps the pancreas produce more insulin, improves insulin sensitivity, and decreases excess glucose production by the liver. It helps control postprandial (after-meal) blood sugar spikes and does not cause weight gain even with long-term use. Istamet 50 mg/1000 mg Tablet plays a vital role in controlling blood sugar levels and helps prevent serious diabetes-related complications, such as:

• Vision loss (retinopathy)

• Kidney damage (nephropathy)

• Nerve damage (neuropathy)

• Diabetic foot ulcers

• Delayed wound healing
  

How to use

Take Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets exactly as prescribed by your doctor. Swallow the tablet whole with water; do not crush, break, or chew it.

Side Effects

• Hypoglycemia (low blood sugar)

• Runny nose

• Sore throat

• Upper respiratory tract infection

• Diarrhea

• Nausea

• Vomiting

• Flatulence (gas)

• Stomach upset

• Indigestion

• General weakness

• Headache

Safety Advice

• Avoid consumption of alcohol while on treatment with Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets, as it may increase the risk of lactic acidosis and hypoglycemia.

• Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets are only recommended during pregnancy if the potential benefits outweigh the risks. Consult your doctor before starting this medication if you are pregnant or planning to conceive.

Storage Conditions

• Store at a temperature below 86°F (30 °C).

FAQs

What is the use of Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablet?

They are used to treat Type 2 Diabetes Mellitus by helping control blood sugar levels

How does Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets work?

Metformin reduces glucose production in the liver, lowers glucose absorption in the gut, and improves insulin sensitivity. Sitagliptin increases incretin hormones, which stimulate insulin release and reduce glucagon secretion, helping regulate blood sugar levels.

What are the signs of diabetes?

Increased hunger, excessive thirst, frequent urination (especially at night), unexplained weight loss, fatigue, blurred vision, slow healing of wounds or sores, and frequent infections.

Are Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets used for the treatment of type 1 diabetes?

No. Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets are only prescribed for the treatment of type 2 diabetes, also called non-insulin-dependent diabetes.

Why do Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets need to be taken with food?

Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets need to be taken with food to avoid stomach upset. Take it as prescribed by your doctor.

Can I take crushed Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets?

Do not crush or chew Sitagliptin Phosphate 50mg & Metformin Hydrochloride 1000mg Tablets, as it may release all of the medicine at once and cause side effects. Take it whole with food, or as directed by your doctor.