Product Description

Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP is a combination drug containing Vildagliptin (a DPP-4 inhibitor) and Metformin (a biguanide), both belonging to the class of anti-diabetics.

It is used for type 2 diabetes mellitus, previously known as non-insulin-dependent diabetes mellitus (NIDDM) or maturity-onset diabetes. 

Type 2 diabetes occurs when the body doesn't produce enough insulin, insulin doesn't work effectively, or there's excess glucagon production. Insulin helps lower blood sugar, especially after meals, while glucagon (produced by the pancreas) signals the liver to release sugar, raising blood glucose.

Uses

Treatment of type 2 diabetes mellitus (as monotherapy or in combination with other antidiabetics).

How it works

Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP combines two mechanisms: Vildagliptin inhibits DPP-4, an enzyme that breaks down GLP-1, leading to increased GLP-1 levels. GLP-1 stimulates insulin release and suppresses glucagon secretion, helping control blood sugar. Metformin reduces glucose production by the liver, improves insulin sensitivity in muscles, and decreases intestinal glucose absorption. Together, they lower blood glucose levels without causing significant weight gain.

Benefits

This tablet helps increase insulin production and utilisation, reduces excess sugar from the liver, and controls blood sugar spikes after meals. It aids in managing type 2 diabetes and may help reduce the risk of complications like diabetic retinopathy (eye damage), nephropathy (kidney damage), neuropathy (nerve damage), foot ulcers, and delayed wound healing. Additional benefits include minimal impact on weight and potential cardiovascular protection. Effectiveness depends on diet, exercise, and adherence.

How to use

Swallow it as a whole with water; do not crush, break, or chew it. Take with meals as advised by your doctor to minimise stomach upset. Dosage varies (e.g., 1 tablet daily); follow your prescription exactly.

Side Effects

• Common: Low blood sugar (hypoglycemia), nausea, headache, shaking, vomiting, diarrhoea, abdominal pain, loss of appetite, joint pain, tiredness, constipation, swollen hands/ankles/feet (oedema).

• Rare but serious: Lactic acidosis (muscle pain, difficulty breathing), pancreatitis, severe allergic reactions (rash, swelling). Contact a doctor if severe or persistent.

Safety Advice

• It is best to avoid alcohol while taking this medication, as it may increase the risk of low blood sugar or lactic acidosis.

• Consult your doctor before use, especially if you have or had liver-related diseases, kidney impairment, heart failure, or are pregnant/breastfeeding.

• Not recommended for severe renal disease or during pregnancy (potential risk to fetus).

• Inform your doctor about all medications (e.g., insulin, diuretics) to avoid interactions.

• Monitor blood sugar, kidney function, and vitamin B12 levels regularly.

Storage Conditions

Store at a temperature below 86°F (30 °C). Protect from light and moisture.

FAQs

How will I know that I am suffering from diabetes?

If you have symptoms like increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing, and frequent infections, contact a doctor as it can be a condition of type 2 diabetes.

If my blood sugar level suddenly goes down, then what should I do?

In case you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It helps regulate blood sugar levels in your body. Therefore, it’s recommended to carry sugar candies with you.

Is Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP also prescribed for the treatment of type 1 diabetes?

No. Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP is only prescribed for the treatment of type 2 diabetes, also called 'non-insulin-dependent diabetes'.

What is type 2 diabetes, and what are its symptoms and complications?

Type 2 diabetes is a prevalent condition where the body's insulin, a hormone that regulates blood sugar, does not work effectively. Due to this, the blood glucose level increases, and symptoms such as frequent urination, increased thirst, and increased hunger start. If diabetes is untreated or poorly managed, it can lead to long-term complications like nerve damage, kidney damage, eye damage, foot issues, and an increased risk of other health problems. developing heart diseases.

How long do I need to take Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP?

Keep taking your medication for the duration prescribed by your doctor.. Your doctor will check your progress to make sure the medicine is working and will discuss with you how long your treatment should continue. Do not stop taking Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP unless your doctor tells you to.

What diet must I follow?

Incorporate a diet abundant in fruits, vegetables, and whole grains such as brown rice, whole wheat, oats, barley, and quinoa. Include non-fat or low-fat dairy and protein sources like chicken, lean meats, nuts, beans, tofu, lentils, eggs, fish, and turkey.

Can I stop taking Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP?

Do not stop taking Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP on your own, as it might cause an increase in blood sugar levels. Contact your doctor if you experience any issues while taking the medication.

What is the best time to take Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP?

Take Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP as advised by the doctor. It can be taken in the morning and evening with or just after food. Taking Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP with food helps lower the risk of stomach upset.

What are the side effects of Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP?

Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP may cause side effects such as nausea, headache, shaking or quivering, vomiting, diarrhoea, abdominal pain, loss of appetite, joint pain, tiredness, constipation, and oedema.

Can the use of Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP lead to hypoglycaemia?

Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP may cause hypoglycaemia (low blood glucose levels), which is characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth, and skin. Consistently check your blood glucose levels and take glucose tablets, juice, or candy if you notice these symptoms.

Can the use of Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP cause nausea and vomiting?

Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP may cause side effects such as nausea and vomiting. If you experience these symptoms, eat smaller meals more often and avoid hard-to-digest food. Take small, frequent sips of water or any other fluids. Consult the doctor if the condition persists or worsens.

Are there any specific contraindications associated with the use of Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP?

Vildagliptin 50 mg & Metformin 500 mg SR Tablet IP is contraindicated in people who are allergic to any of its components. It is not suitable for those with uncontrolled diabetes, ketoacidosis, severely compromised kidney function, severe infections, heart failure, or major blood circulation issues.